Abstract
Background and aims: To evaluate the efficacy of orbital radiotherapy (OR) for the treatment of thyroid eye disease (TED). Methods: Thirty-five consecutive patients with active TED with contraindications to steroid therapy received a course of OR. Bilateral retrobulbar irradiation was performed with a total dose of 20 Gy. 7-points clinical activity score (7-CAS), ocular motility, visual acuity (VA), exophthalmos and eyelid retraction were prospectively evaluated at 3, 6 and 12 months and compared with baseline data. Results: There was a statistically significant improvement in 7-CAS at 3, 6 and 12 months post-treatment (p < 0.05). Ocular motility disturbances improved at 6 and 12 months (p < 0.05). Visual acuity remained stable; there was no significant change in exophthalmos (mean 24 mm, SD 3 mm) or eyelid retraction (marginal reflex distance mean 6 mm, SD 1.5 mm) during the follow-up period. No side effects were registered. Conclusions: This study suggests that OR might be effective in reducing 7-CAS and ocular motility disturbances. No significant improvement in proptosis or eyelid retraction should be expected from this treatment. OR might be considered a suitable alternative treatment in TED for patients who cannot tolerate steroids.
| Original language | English |
|---|---|
| Pages (from-to) | 647-652 |
| Number of pages | 6 |
| Journal | Irish Journal of Medical Science |
| Volume | 186 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Aug 1 2017 |
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Keywords
- Alternative first-line therapy
- Graves ophthalmopathy
- Orbital radiotherapy
- Thyroid eye disease
ASJC Scopus subject areas
- Medicine(all)
Cite this
Radiotherapy for the treatment of thyroid eye disease—a prospective comparison : Is orbital radiotherapy a suitable alternative to steroids? / Grassi, P.; Strianese, D.; Piscopo, R.; Pacelli, R.; Bonavolontà, G.
In: Irish Journal of Medical Science, Vol. 186, No. 3, 01.08.2017, p. 647-652.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Radiotherapy for the treatment of thyroid eye disease—a prospective comparison
T2 - Is orbital radiotherapy a suitable alternative to steroids?
AU - Grassi, P.
AU - Strianese, D.
AU - Piscopo, R.
AU - Pacelli, R.
AU - Bonavolontà, G.
PY - 2017/8/1
Y1 - 2017/8/1
N2 - Background and aims: To evaluate the efficacy of orbital radiotherapy (OR) for the treatment of thyroid eye disease (TED). Methods: Thirty-five consecutive patients with active TED with contraindications to steroid therapy received a course of OR. Bilateral retrobulbar irradiation was performed with a total dose of 20 Gy. 7-points clinical activity score (7-CAS), ocular motility, visual acuity (VA), exophthalmos and eyelid retraction were prospectively evaluated at 3, 6 and 12 months and compared with baseline data. Results: There was a statistically significant improvement in 7-CAS at 3, 6 and 12 months post-treatment (p < 0.05). Ocular motility disturbances improved at 6 and 12 months (p < 0.05). Visual acuity remained stable; there was no significant change in exophthalmos (mean 24 mm, SD 3 mm) or eyelid retraction (marginal reflex distance mean 6 mm, SD 1.5 mm) during the follow-up period. No side effects were registered. Conclusions: This study suggests that OR might be effective in reducing 7-CAS and ocular motility disturbances. No significant improvement in proptosis or eyelid retraction should be expected from this treatment. OR might be considered a suitable alternative treatment in TED for patients who cannot tolerate steroids.
AB - Background and aims: To evaluate the efficacy of orbital radiotherapy (OR) for the treatment of thyroid eye disease (TED). Methods: Thirty-five consecutive patients with active TED with contraindications to steroid therapy received a course of OR. Bilateral retrobulbar irradiation was performed with a total dose of 20 Gy. 7-points clinical activity score (7-CAS), ocular motility, visual acuity (VA), exophthalmos and eyelid retraction were prospectively evaluated at 3, 6 and 12 months and compared with baseline data. Results: There was a statistically significant improvement in 7-CAS at 3, 6 and 12 months post-treatment (p < 0.05). Ocular motility disturbances improved at 6 and 12 months (p < 0.05). Visual acuity remained stable; there was no significant change in exophthalmos (mean 24 mm, SD 3 mm) or eyelid retraction (marginal reflex distance mean 6 mm, SD 1.5 mm) during the follow-up period. No side effects were registered. Conclusions: This study suggests that OR might be effective in reducing 7-CAS and ocular motility disturbances. No significant improvement in proptosis or eyelid retraction should be expected from this treatment. OR might be considered a suitable alternative treatment in TED for patients who cannot tolerate steroids.
KW - Alternative first-line therapy
KW - Graves ophthalmopathy
KW - Orbital radiotherapy
KW - Thyroid eye disease
UR - http://www.scopus.com/inward/record.url?scp=85008162817&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85008162817&partnerID=8YFLogxK
U2 - 10.1007/s11845-016-1542-3
DO - 10.1007/s11845-016-1542-3
M3 - Article
AN - SCOPUS:85008162817
VL - 186
SP - 647
EP - 652
JO - The Dublin Journal of Medical and Chemical Science
JF - The Dublin Journal of Medical and Chemical Science
SN - 0332-1029
IS - 3
ER -