Radiotherapy for vulvar carcinoma with positive inguinal nodes: Adjunctive treatment

L. Mariani, A. Lombardi, M. Atlante, G. Atlante

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Between 1981 and 1988, 58 patients with vulvar carcinoma underwent radical vulvectomy and unilateral inguinal lymphadenectomy. Sixteen patients with inguinal node metastases received complementary radiotherapy as an alternative to pelvic node dissection. They were treated with Co-60 therapy for bilateral inguinal and pelvic lymph nodes. The overall five-year actuarial survival rate in patients without node involvement was 84%; in patients with positive inguinal nodes treated with the combined radiosurgical approach, it was 64%. Patients with 1 node involved had a 74% rate of estimated survival, and those with 2 or more metastatic nodes, considered to be at high risk, had an estimated survival rate of 49%. Only mild to moderate side effects related to the radiation therapy were observed, and in no case was it necessary to interrupt the treatment. In terms of survival, the results obtained in the group of patients with postoperative radiotherapy were better than those normally expected after pelvic lymphadenectomy, and as suggested in recent literature, point to the promising role of irradiation as adjuvant management for vulvar cancer with node involvement.

Original languageEnglish
Pages (from-to)429-437
Number of pages9
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume38
Issue number6
Publication statusPublished - 1993

Fingerprint

Groin
Radiotherapy
Carcinoma
Survival Rate
Lymph Node Excision
Therapeutics
Vulvar Neoplasms
Dissection
Lymph Nodes
Neoplasm Metastasis
Survival

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Radiotherapy for vulvar carcinoma with positive inguinal nodes : Adjunctive treatment. / Mariani, L.; Lombardi, A.; Atlante, M.; Atlante, G.

In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist, Vol. 38, No. 6, 1993, p. 429-437.

Research output: Contribution to journalArticle

@article{15d1a4ad2da24e5b83ba38df25cc13fb,
title = "Radiotherapy for vulvar carcinoma with positive inguinal nodes: Adjunctive treatment",
abstract = "Between 1981 and 1988, 58 patients with vulvar carcinoma underwent radical vulvectomy and unilateral inguinal lymphadenectomy. Sixteen patients with inguinal node metastases received complementary radiotherapy as an alternative to pelvic node dissection. They were treated with Co-60 therapy for bilateral inguinal and pelvic lymph nodes. The overall five-year actuarial survival rate in patients without node involvement was 84{\%}; in patients with positive inguinal nodes treated with the combined radiosurgical approach, it was 64{\%}. Patients with 1 node involved had a 74{\%} rate of estimated survival, and those with 2 or more metastatic nodes, considered to be at high risk, had an estimated survival rate of 49{\%}. Only mild to moderate side effects related to the radiation therapy were observed, and in no case was it necessary to interrupt the treatment. In terms of survival, the results obtained in the group of patients with postoperative radiotherapy were better than those normally expected after pelvic lymphadenectomy, and as suggested in recent literature, point to the promising role of irradiation as adjuvant management for vulvar cancer with node involvement.",
author = "L. Mariani and A. Lombardi and M. Atlante and G. Atlante",
year = "1993",
language = "English",
volume = "38",
pages = "429--437",
journal = "The Journal of reproductive medicine",
issn = "0024-7758",
publisher = "Donna Kessel",
number = "6",

}

TY - JOUR

T1 - Radiotherapy for vulvar carcinoma with positive inguinal nodes

T2 - Adjunctive treatment

AU - Mariani, L.

AU - Lombardi, A.

AU - Atlante, M.

AU - Atlante, G.

PY - 1993

Y1 - 1993

N2 - Between 1981 and 1988, 58 patients with vulvar carcinoma underwent radical vulvectomy and unilateral inguinal lymphadenectomy. Sixteen patients with inguinal node metastases received complementary radiotherapy as an alternative to pelvic node dissection. They were treated with Co-60 therapy for bilateral inguinal and pelvic lymph nodes. The overall five-year actuarial survival rate in patients without node involvement was 84%; in patients with positive inguinal nodes treated with the combined radiosurgical approach, it was 64%. Patients with 1 node involved had a 74% rate of estimated survival, and those with 2 or more metastatic nodes, considered to be at high risk, had an estimated survival rate of 49%. Only mild to moderate side effects related to the radiation therapy were observed, and in no case was it necessary to interrupt the treatment. In terms of survival, the results obtained in the group of patients with postoperative radiotherapy were better than those normally expected after pelvic lymphadenectomy, and as suggested in recent literature, point to the promising role of irradiation as adjuvant management for vulvar cancer with node involvement.

AB - Between 1981 and 1988, 58 patients with vulvar carcinoma underwent radical vulvectomy and unilateral inguinal lymphadenectomy. Sixteen patients with inguinal node metastases received complementary radiotherapy as an alternative to pelvic node dissection. They were treated with Co-60 therapy for bilateral inguinal and pelvic lymph nodes. The overall five-year actuarial survival rate in patients without node involvement was 84%; in patients with positive inguinal nodes treated with the combined radiosurgical approach, it was 64%. Patients with 1 node involved had a 74% rate of estimated survival, and those with 2 or more metastatic nodes, considered to be at high risk, had an estimated survival rate of 49%. Only mild to moderate side effects related to the radiation therapy were observed, and in no case was it necessary to interrupt the treatment. In terms of survival, the results obtained in the group of patients with postoperative radiotherapy were better than those normally expected after pelvic lymphadenectomy, and as suggested in recent literature, point to the promising role of irradiation as adjuvant management for vulvar cancer with node involvement.

UR - http://www.scopus.com/inward/record.url?scp=0027155842&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027155842&partnerID=8YFLogxK

M3 - Article

C2 - 8331621

AN - SCOPUS:0027155842

VL - 38

SP - 429

EP - 437

JO - The Journal of reproductive medicine

JF - The Journal of reproductive medicine

SN - 0024-7758

IS - 6

ER -