Radiotherapy in the multidisciplinary treatment of liver cancer

a survey on behalf of the Italian Association of Radiation Oncology

Francesco Dionisi, Alessia Guarneri, Veronica Dell'Acqua, Maria Cristina Leonardi, Rita Niespolo, Gabriella Macchia, Tizian Comito, Maurizio Amichetti, Pierfrancesco Franco, S. Cilla, Luciana Caravatta, Filippo Alongi, Giovanna Mantello

Research output: Contribution to journalArticle

Abstract

Purpose: To report the results of the first Italian survey investigating the role of liver-directed radiotherapy in the multidisciplinary approach of primary and metastatic liver cancer. Materials and methods: A 21-item, two-section questionnaire was sent to all Italian radiotherapy centers on June 2014. The two sections aimed at: (1) evaluating the presence of a multidisciplinary liver tumor board and describing the role of radiation oncologists within the latter, (2) analyzing Radiotherapy treatment details and differences between centers. Results: A total of 37 centers completed the survey. A multidisciplinary liver tumor board was available in most centers (73 %), with a radiation oncologist routinely attending the latter in the majority of cases (85 %). Most of the respondents considered liver-directed Radiotherapy as the third line choice when other therapies were not indicated or technically suitable. 18 centers reported the use of liver-directed radiotherapy. The majority of centers started liver irradiation after 2010. The most adopted motion management strategy was abdominal compression. The most adopted GTV-CTV expansion was 0 and 5 mm for metastases and hepatocellular carcinoma, respectively. Stereotactic body radiotherapy was the technique of choice; several treatment schedules were registered, being 45 Gy in three fractions the most reported fractionation scheme. Dose was prescribed at the PTV margin in most cases. Conclusion: Liver-directed radiotherapy represents a new field of interest which is currently adopted by 10 % of all Italian Centers. The technical equipment seems adequate. The variations observed in the treatment regimens reflect the lack of a well-established standard schedule.

Original languageEnglish
Pages (from-to)735-743
Number of pages9
JournalRadiologia Medica
Volume121
Issue number9
DOIs
Publication statusPublished - Sep 1 2016

Fingerprint

Radiation Oncology
Liver Neoplasms
Radiotherapy
Liver
Therapeutics
Appointments and Schedules
Radiosurgery
Surveys and Questionnaires
Hepatocellular Carcinoma
Neoplasms
Neoplasm Metastasis
Equipment and Supplies

Keywords

  • HCC
  • Liver metastases
  • Radiotherapy
  • SBRT

ASJC Scopus subject areas

  • Medicine(all)
  • Radiology Nuclear Medicine and imaging

Cite this

Radiotherapy in the multidisciplinary treatment of liver cancer : a survey on behalf of the Italian Association of Radiation Oncology. / Dionisi, Francesco; Guarneri, Alessia; Dell'Acqua, Veronica; Leonardi, Maria Cristina; Niespolo, Rita; Macchia, Gabriella; Comito, Tizian; Amichetti, Maurizio; Franco, Pierfrancesco; Cilla, S.; Caravatta, Luciana; Alongi, Filippo; Mantello, Giovanna.

In: Radiologia Medica, Vol. 121, No. 9, 01.09.2016, p. 735-743.

Research output: Contribution to journalArticle

Dionisi, F, Guarneri, A, Dell'Acqua, V, Leonardi, MC, Niespolo, R, Macchia, G, Comito, T, Amichetti, M, Franco, P, Cilla, S, Caravatta, L, Alongi, F & Mantello, G 2016, 'Radiotherapy in the multidisciplinary treatment of liver cancer: a survey on behalf of the Italian Association of Radiation Oncology', Radiologia Medica, vol. 121, no. 9, pp. 735-743. https://doi.org/10.1007/s11547-016-0650-5
Dionisi, Francesco ; Guarneri, Alessia ; Dell'Acqua, Veronica ; Leonardi, Maria Cristina ; Niespolo, Rita ; Macchia, Gabriella ; Comito, Tizian ; Amichetti, Maurizio ; Franco, Pierfrancesco ; Cilla, S. ; Caravatta, Luciana ; Alongi, Filippo ; Mantello, Giovanna. / Radiotherapy in the multidisciplinary treatment of liver cancer : a survey on behalf of the Italian Association of Radiation Oncology. In: Radiologia Medica. 2016 ; Vol. 121, No. 9. pp. 735-743.
@article{154006352dc446dba97975e5f1192882,
title = "Radiotherapy in the multidisciplinary treatment of liver cancer: a survey on behalf of the Italian Association of Radiation Oncology",
abstract = "Purpose: To report the results of the first Italian survey investigating the role of liver-directed radiotherapy in the multidisciplinary approach of primary and metastatic liver cancer. Materials and methods: A 21-item, two-section questionnaire was sent to all Italian radiotherapy centers on June 2014. The two sections aimed at: (1) evaluating the presence of a multidisciplinary liver tumor board and describing the role of radiation oncologists within the latter, (2) analyzing Radiotherapy treatment details and differences between centers. Results: A total of 37 centers completed the survey. A multidisciplinary liver tumor board was available in most centers (73 {\%}), with a radiation oncologist routinely attending the latter in the majority of cases (85 {\%}). Most of the respondents considered liver-directed Radiotherapy as the third line choice when other therapies were not indicated or technically suitable. 18 centers reported the use of liver-directed radiotherapy. The majority of centers started liver irradiation after 2010. The most adopted motion management strategy was abdominal compression. The most adopted GTV-CTV expansion was 0 and 5 mm for metastases and hepatocellular carcinoma, respectively. Stereotactic body radiotherapy was the technique of choice; several treatment schedules were registered, being 45 Gy in three fractions the most reported fractionation scheme. Dose was prescribed at the PTV margin in most cases. Conclusion: Liver-directed radiotherapy represents a new field of interest which is currently adopted by 10 {\%} of all Italian Centers. The technical equipment seems adequate. The variations observed in the treatment regimens reflect the lack of a well-established standard schedule.",
keywords = "HCC, Liver metastases, Radiotherapy, SBRT",
author = "Francesco Dionisi and Alessia Guarneri and Veronica Dell'Acqua and Leonardi, {Maria Cristina} and Rita Niespolo and Gabriella Macchia and Tizian Comito and Maurizio Amichetti and Pierfrancesco Franco and S. Cilla and Luciana Caravatta and Filippo Alongi and Giovanna Mantello",
year = "2016",
month = "9",
day = "1",
doi = "10.1007/s11547-016-0650-5",
language = "English",
volume = "121",
pages = "735--743",
journal = "Radiologia Medica",
issn = "0033-8362",
publisher = "Springer-Verlag Italia s.r.l.",
number = "9",

}

TY - JOUR

T1 - Radiotherapy in the multidisciplinary treatment of liver cancer

T2 - a survey on behalf of the Italian Association of Radiation Oncology

AU - Dionisi, Francesco

AU - Guarneri, Alessia

AU - Dell'Acqua, Veronica

AU - Leonardi, Maria Cristina

AU - Niespolo, Rita

AU - Macchia, Gabriella

AU - Comito, Tizian

AU - Amichetti, Maurizio

AU - Franco, Pierfrancesco

AU - Cilla, S.

AU - Caravatta, Luciana

AU - Alongi, Filippo

AU - Mantello, Giovanna

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Purpose: To report the results of the first Italian survey investigating the role of liver-directed radiotherapy in the multidisciplinary approach of primary and metastatic liver cancer. Materials and methods: A 21-item, two-section questionnaire was sent to all Italian radiotherapy centers on June 2014. The two sections aimed at: (1) evaluating the presence of a multidisciplinary liver tumor board and describing the role of radiation oncologists within the latter, (2) analyzing Radiotherapy treatment details and differences between centers. Results: A total of 37 centers completed the survey. A multidisciplinary liver tumor board was available in most centers (73 %), with a radiation oncologist routinely attending the latter in the majority of cases (85 %). Most of the respondents considered liver-directed Radiotherapy as the third line choice when other therapies were not indicated or technically suitable. 18 centers reported the use of liver-directed radiotherapy. The majority of centers started liver irradiation after 2010. The most adopted motion management strategy was abdominal compression. The most adopted GTV-CTV expansion was 0 and 5 mm for metastases and hepatocellular carcinoma, respectively. Stereotactic body radiotherapy was the technique of choice; several treatment schedules were registered, being 45 Gy in three fractions the most reported fractionation scheme. Dose was prescribed at the PTV margin in most cases. Conclusion: Liver-directed radiotherapy represents a new field of interest which is currently adopted by 10 % of all Italian Centers. The technical equipment seems adequate. The variations observed in the treatment regimens reflect the lack of a well-established standard schedule.

AB - Purpose: To report the results of the first Italian survey investigating the role of liver-directed radiotherapy in the multidisciplinary approach of primary and metastatic liver cancer. Materials and methods: A 21-item, two-section questionnaire was sent to all Italian radiotherapy centers on June 2014. The two sections aimed at: (1) evaluating the presence of a multidisciplinary liver tumor board and describing the role of radiation oncologists within the latter, (2) analyzing Radiotherapy treatment details and differences between centers. Results: A total of 37 centers completed the survey. A multidisciplinary liver tumor board was available in most centers (73 %), with a radiation oncologist routinely attending the latter in the majority of cases (85 %). Most of the respondents considered liver-directed Radiotherapy as the third line choice when other therapies were not indicated or technically suitable. 18 centers reported the use of liver-directed radiotherapy. The majority of centers started liver irradiation after 2010. The most adopted motion management strategy was abdominal compression. The most adopted GTV-CTV expansion was 0 and 5 mm for metastases and hepatocellular carcinoma, respectively. Stereotactic body radiotherapy was the technique of choice; several treatment schedules were registered, being 45 Gy in three fractions the most reported fractionation scheme. Dose was prescribed at the PTV margin in most cases. Conclusion: Liver-directed radiotherapy represents a new field of interest which is currently adopted by 10 % of all Italian Centers. The technical equipment seems adequate. The variations observed in the treatment regimens reflect the lack of a well-established standard schedule.

KW - HCC

KW - Liver metastases

KW - Radiotherapy

KW - SBRT

UR - http://www.scopus.com/inward/record.url?scp=84983033996&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84983033996&partnerID=8YFLogxK

U2 - 10.1007/s11547-016-0650-5

DO - 10.1007/s11547-016-0650-5

M3 - Article

VL - 121

SP - 735

EP - 743

JO - Radiologia Medica

JF - Radiologia Medica

SN - 0033-8362

IS - 9

ER -