Radiotherapy of Kaposi's Sarcoma

Kaposi‘s sarcoma is an endothelial neoplasm that presents in different clinical settings with possible skin, mucosa, lymph node and visceral localizations. Treatment requires to be personalized on the basis of clinical picture. Radiotherapy may play a role in the control of the cutaneous and oral mucosa disease, when localized, and in palliation in case of pain or ulcerated lesions. The experience of the authors on a large series of patients confirms that optimal biologic dose of ionizing radiation to be administered is about 30 Gy and that radiotherapy is a therapeutic tool with a favourable benefit/risk ratio.