Radiotherapy of prostate carcinoma: A comparison of the predictive role of EAU versus NCCN risk stratification systems

Milly Buwenge; Francesco Deodato; Naama Dominsky; Maria Ntreta; Savino Cilla; Giambattista Siepe; Anna Rita Alitto; Silvia Bisello; Vincenzo Valentini; Gabriella Macchia; Alessio G. Morganti

doi:10.21873/anticanres.14446

Radiotherapy of prostate carcinoma: A comparison of the predictive role of EAU versus NCCN risk stratification systems

Milly Buwenge, Francesco Deodato, Naama Dominsky, Maria Ntreta, Savino Cilla, Giambattista Siepe, Anna Rita Alitto, Silvia Bisello, Vincenzo Valentini, Gabriella Macchia, Alessio G. Morganti

IRCCS Fondazione Policlinico Universitario A. Gemelli

Research output: Contribution to journal › Article › peer-review

Abstract

Background/Aim: To compare the predictive efficacy of National Comprehensive Cancer Network (NCCN) and European Association of Urology (EAU) risk stratification systems in radiotherapy of prostate cancer. Patients and Methods: One-thousand-nine-hundred-nine patients treated with definitive (1,074), adjuvant (381), and salvage radiotherapy (454) were analysed. Results: Both systems significantly predicted biochemical-relapse-free-survival, metastasis-freesurvival, and disease-free-survival, while only the NCCN system correlated with local-control in the definitive radiotherapy group. In the adjuvant setting, both systems failed to predict all outcomes. In the salvage setting, only the NCCN system significantly predicted biochemical-relapse-free-survival, metastasis-free-survival and disease-free-survival. Conclusion: This analysis confirms the efficacy of both systems in definitive radiotherapy and suggests the utility of the NCCN also in salvage radiotherapy.

Original language	English
Pages (from-to)	4413-4418
Number of pages	6
Journal	Anticancer Research
Volume	40
Issue number	8
DOIs	https://doi.org/10.21873/anticanres.14446
Publication status	Published - Aug 2020

Keywords

EAU
NCCN
Prostate neoplasms
Radiotherapy
Risk stratification systems

ASJC Scopus subject areas

Oncology
Cancer Research

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Radiotherapy of prostate carcinoma : A comparison of the predictive role of EAU versus NCCN risk stratification systems. / Buwenge, Milly; Deodato, Francesco; Dominsky, Naama; Ntreta, Maria; Cilla, Savino; Siepe, Giambattista; Alitto, Anna Rita; Bisello, Silvia; Valentini, Vincenzo; Macchia, Gabriella; Morganti, Alessio G.

In: Anticancer Research, Vol. 40, No. 8, 08.2020, p. 4413-4418.

Research output: Contribution to journal › Article › peer-review

Buwenge, Milly ; Deodato, Francesco ; Dominsky, Naama ; Ntreta, Maria ; Cilla, Savino ; Siepe, Giambattista ; Alitto, Anna Rita ; Bisello, Silvia ; Valentini, Vincenzo ; Macchia, Gabriella ; Morganti, Alessio G. / Radiotherapy of prostate carcinoma : A comparison of the predictive role of EAU versus NCCN risk stratification systems. In: Anticancer Research. 2020 ; Vol. 40, No. 8. pp. 4413-4418.

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abstract = "Background/Aim: To compare the predictive efficacy of National Comprehensive Cancer Network (NCCN) and European Association of Urology (EAU) risk stratification systems in radiotherapy of prostate cancer. Patients and Methods: One-thousand-nine-hundred-nine patients treated with definitive (1,074), adjuvant (381), and salvage radiotherapy (454) were analysed. Results: Both systems significantly predicted biochemical-relapse-free-survival, metastasis-freesurvival, and disease-free-survival, while only the NCCN system correlated with local-control in the definitive radiotherapy group. In the adjuvant setting, both systems failed to predict all outcomes. In the salvage setting, only the NCCN system significantly predicted biochemical-relapse-free-survival, metastasis-free-survival and disease-free-survival. Conclusion: This analysis confirms the efficacy of both systems in definitive radiotherapy and suggests the utility of the NCCN also in salvage radiotherapy.",

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author = "Milly Buwenge and Francesco Deodato and Naama Dominsky and Maria Ntreta and Savino Cilla and Giambattista Siepe and Alitto, {Anna Rita} and Silvia Bisello and Vincenzo Valentini and Gabriella Macchia and Morganti, {Alessio G.}",

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doi = "10.21873/anticanres.14446",

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AU - Dominsky, Naama

AU - Ntreta, Maria

AU - Cilla, Savino

AU - Siepe, Giambattista

AU - Alitto, Anna Rita

AU - Bisello, Silvia

AU - Valentini, Vincenzo

AU - Macchia, Gabriella

AU - Morganti, Alessio G.

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N2 - Background/Aim: To compare the predictive efficacy of National Comprehensive Cancer Network (NCCN) and European Association of Urology (EAU) risk stratification systems in radiotherapy of prostate cancer. Patients and Methods: One-thousand-nine-hundred-nine patients treated with definitive (1,074), adjuvant (381), and salvage radiotherapy (454) were analysed. Results: Both systems significantly predicted biochemical-relapse-free-survival, metastasis-freesurvival, and disease-free-survival, while only the NCCN system correlated with local-control in the definitive radiotherapy group. In the adjuvant setting, both systems failed to predict all outcomes. In the salvage setting, only the NCCN system significantly predicted biochemical-relapse-free-survival, metastasis-free-survival and disease-free-survival. Conclusion: This analysis confirms the efficacy of both systems in definitive radiotherapy and suggests the utility of the NCCN also in salvage radiotherapy.

AB - Background/Aim: To compare the predictive efficacy of National Comprehensive Cancer Network (NCCN) and European Association of Urology (EAU) risk stratification systems in radiotherapy of prostate cancer. Patients and Methods: One-thousand-nine-hundred-nine patients treated with definitive (1,074), adjuvant (381), and salvage radiotherapy (454) were analysed. Results: Both systems significantly predicted biochemical-relapse-free-survival, metastasis-freesurvival, and disease-free-survival, while only the NCCN system correlated with local-control in the definitive radiotherapy group. In the adjuvant setting, both systems failed to predict all outcomes. In the salvage setting, only the NCCN system significantly predicted biochemical-relapse-free-survival, metastasis-free-survival and disease-free-survival. Conclusion: This analysis confirms the efficacy of both systems in definitive radiotherapy and suggests the utility of the NCCN also in salvage radiotherapy.

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Radiotherapy of prostate carcinoma: A comparison of the predictive role of EAU versus NCCN risk stratification systems

Abstract

Keywords

ASJC Scopus subject areas

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