Radiotherapy of prostate carcinoma: A comparison of the predictive role of EAU versus NCCN risk stratification systems

Milly Buwenge, Francesco Deodato, Naama Dominsky, Maria Ntreta, Savino Cilla, Giambattista Siepe, Anna Rita Alitto, Silvia Bisello, Vincenzo Valentini, Gabriella Macchia, Alessio G. Morganti

Research output: Contribution to journalArticlepeer-review

Abstract

Background/Aim: To compare the predictive efficacy of National Comprehensive Cancer Network (NCCN) and European Association of Urology (EAU) risk stratification systems in radiotherapy of prostate cancer. Patients and Methods: One-thousand-nine-hundred-nine patients treated with definitive (1,074), adjuvant (381), and salvage radiotherapy (454) were analysed. Results: Both systems significantly predicted biochemical-relapse-free-survival, metastasis-freesurvival, and disease-free-survival, while only the NCCN system correlated with local-control in the definitive radiotherapy group. In the adjuvant setting, both systems failed to predict all outcomes. In the salvage setting, only the NCCN system significantly predicted biochemical-relapse-free-survival, metastasis-free-survival and disease-free-survival. Conclusion: This analysis confirms the efficacy of both systems in definitive radiotherapy and suggests the utility of the NCCN also in salvage radiotherapy.

Original languageEnglish
Pages (from-to)4413-4418
Number of pages6
JournalAnticancer Research
Volume40
Issue number8
DOIs
Publication statusPublished - Aug 2020

Keywords

  • EAU
  • NCCN
  • Prostate neoplasms
  • Radiotherapy
  • Risk stratification systems

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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