TY - JOUR
T1 - Radiotherapy of residual (incompletely excised) basal and squamous-cell carcinomas of the skin. Experience in 87 cases with no evidence of clinical disease
AU - Caccialanza, M.
AU - Piccinno, R.
AU - Bottelli, S.
AU - Franchi, C.
PY - 2001
Y1 - 2001
N2 - Background. Incompletely excised basal and squamous cell carcinomas of the skin (with histopathological ascertainment) with no evidence of clinical disease represent a yet unsolved therapeutic problem. Aim of this study was to evaluate whether radiotherapy was or not a safe and effective treatment in destroying the residual neoplastic cells and to prevent and/or reduce the onset of clinically evident relapses. Methods. Therefore, a retrospective study was performed on 87 patients (77 with basal cell carcinoma and 10 with squamous cell carcinoma), that underwent orthovoltage radiotherapy in the period 1982-1999. The total doses administered ranged from 50 to 60 Gy. The mean follow-up was 46.37 months, planned according to a schedule of a first control 1 month after the end of radiotherapy, then a control every sixth month for 5 years, and a control once in a year. The cure-rate was evaluated according to the life-table method. Results. The five-year cure-rate (after the end of radiotherapy) was 90.4%. Five recurrences have been observed in basal cell carcinomas, 2 centrally and 3 marginally respect to the irradiation field. The cosmetic results were evaluated as good or acceptable in 81% of cases. So far no complications nor sequelae to the treatment have been observed. Conclusions. Radiotherapy has resulted as a safe and effective treatment with a low cost in the management of this kind of skin neoplasms.
AB - Background. Incompletely excised basal and squamous cell carcinomas of the skin (with histopathological ascertainment) with no evidence of clinical disease represent a yet unsolved therapeutic problem. Aim of this study was to evaluate whether radiotherapy was or not a safe and effective treatment in destroying the residual neoplastic cells and to prevent and/or reduce the onset of clinically evident relapses. Methods. Therefore, a retrospective study was performed on 87 patients (77 with basal cell carcinoma and 10 with squamous cell carcinoma), that underwent orthovoltage radiotherapy in the period 1982-1999. The total doses administered ranged from 50 to 60 Gy. The mean follow-up was 46.37 months, planned according to a schedule of a first control 1 month after the end of radiotherapy, then a control every sixth month for 5 years, and a control once in a year. The cure-rate was evaluated according to the life-table method. Results. The five-year cure-rate (after the end of radiotherapy) was 90.4%. Five recurrences have been observed in basal cell carcinomas, 2 centrally and 3 marginally respect to the irradiation field. The cosmetic results were evaluated as good or acceptable in 81% of cases. So far no complications nor sequelae to the treatment have been observed. Conclusions. Radiotherapy has resulted as a safe and effective treatment with a low cost in the management of this kind of skin neoplasms.
KW - Carcinoma, basal cell
KW - Carcinoma, squamous cell
KW - Radiotherapy
KW - Skin neoplasms, surgery
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M3 - Article
AN - SCOPUS:0035695704
VL - 136
SP - 329
EP - 333
JO - Minerva dermatologica
JF - Minerva dermatologica
SN - 0392-0488
IS - 5
ER -