Radiotherapy Plus GnRH Analogue Versus High Dose Bicalutamide: A Case Control Study

Milly Buwenge, Francesco Deodato, Gabriella Macchia, Giambattista Siepe, Xiao Zhao, Richard K Valicenti, Savino Cilla, Anna Rita Alitto, Maria Ntreta, Silvia Bisello, Giovanna Mantini, Vincenzo Valentini, Alessio G Morganti, Silvia Cammelli

Research output: Contribution to journalArticlepeer-review


BACKGROUND/AIM: Radiotherapy (RT) with adjuvant hormone therapy (HT) improves prognosis in prostate cancer (PC) patients. Gonadotrophin-releasing hormone agonist (GnRHa) with luteinizing hormone-releasing hormone (LH-RH) analogues is the standard HT. High-dose antiandrogen therapy also improves survival in patients with locally advanced PC. The aim of this study was to compare the results of patients treated with RT plus GnRHa and patients treated with RT plus bicalutamide.

PATIENTS AND METHODS: Our institutional PC database was used to identify patients treated with definitive or postoperative RT +/- HT which were included in this study.

RESULTS: Three hundred and eighteen patients were retrospectively reviewed (median follow-up=56 months). Five-year biochemical relapse-free survival was 85.5% and 88.3% in patients treated with GnRHa and bicalutamide, respectively (p=0.712).

CONCLUSION: Bicalutamide may be offered as an adjuvant treatment to RT in patients who refuse GnRHa because of related side effects. Furthermore, our study justifies randomized trials comparing RT plus GnRHa and RT plus bicalutamide.

Original languageEnglish
Pages (from-to)6373-6378
Number of pages6
JournalAnticancer Research
Issue number11
Publication statusPublished - Nov 2019


  • Aged
  • Aged, 80 and over
  • Androgen Antagonists/administration & dosage
  • Anilides/administration & dosage
  • Antineoplastic Agents, Hormonal/administration & dosage
  • Case-Control Studies
  • Combined Modality Therapy/methods
  • Gonadotropin-Releasing Hormone/agonists
  • Humans
  • Male
  • Middle Aged
  • Nitriles/administration & dosage
  • Prognosis
  • Prostate-Specific Antigen/blood
  • Prostatic Neoplasms/drug therapy
  • Retrospective Studies
  • Tosyl Compounds/administration & dosage


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