RAG and RAG defects

Luigi D. Notarangelo, Anna Villa, Klaus Schwarz

Research output: Contribution to journalArticlepeer-review


Products of the recombination-activating gene (RAG) play a crucial role in lymphoid cell development. During the past year, the functional properties of RAG protein domains have been better defined. Some mutations that alter the amino acid sequence of RAG1 or RAG2 have been shown to disturb B cell generation and to partially disturb T cell generation, resulting in Omenn syndrome in humans; moreover, peripheral re-expression of RAGs indicates their role in lymphoid cell homeostasis.

Original languageEnglish
Pages (from-to)435-442
Number of pages8
JournalCurrent Opinion in Immunology
Issue number4
Publication statusPublished - Aug 1999

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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