RAGE axis: Animal models and novel insights into the vascular complications of diabetes

Yoshifumi Naka, Loredana G. Bucciarelli, Thoralf Wendt, Larisse K. Lee, Ling Rong Ling, Ravichandran Ramasamy, Fang Yan Shi, Ann Marie Schmidt

Research output: Contribution to journalArticlepeer-review

Abstract

Receptor for AGE (RAGE) is a multi-ligand member of the immunoglobulin superfamily of cell surface molecules. Engagement of RAGE by its signal transduction ligands evokes inflammatory cell infiltration and activation in the vessel wall. In diabetes, when fueled by oxidant stress, hyperglycemia, and superimposed stresses such as hyperlipidemia or acute balloon/endothelial denuding arterial injury, the ligand-RAGE axis amplifies vascular stress and accelerates atherosclerosis and neointimal expansion. In this brief synopsis, we review the use of rodent models to test these concepts. Taken together, our findings support the premise that RAGE is an amplification step in vascular inflammation and acceleration of atherosclerosis. Future studies must rigorously test the potential impact of RAGE blockade in human subjects; such trials are on the horizon.

Original languageEnglish
Pages (from-to)1342-1349
Number of pages8
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume24
Issue number8
DOIs
Publication statusPublished - Aug 2004

Keywords

  • Animal models
  • Diabetes
  • Inflammation
  • Receptors
  • Signal transduction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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