Abstract
RAGE is a multiligand receptor able to bind advanced glycation end-products (AGEs), amphoterin, calgranulins, and amyloid-beta peptides, identified in many tissues and cells, including neurons. RAGE stimulation induces the generation of reactive oxygen species (ROS) mainly through the activity of NADPH oxidases. In neuronal cells, RAGE-induced ROS generation is able to favor cell survival and differentiation or to induce death through the imbalance of redox state. The dual nature of RAGE signaling in neurons depends not only on the intensity of RAGE activation but also on the ability of RAGE-bearing cells to adapt to ROS generation. In this review we highlight these aspects of RAGE signaling regulation in neuronal cells.
| Original language | English |
|---|---|
| Article number | 9348651 |
| Journal | Oxidative Medicine and Cellular Longevity |
| Volume | 2016 |
| DOIs | |
| Publication status | Published - 2016 |
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ASJC Scopus subject areas
- Biochemistry
- Ageing
- Cell Biology
Cite this
RAGE Expression and ROS Generation in Neurons : Differentiation versus Damage. / Piras, S.; Furfaro, Annalisa; Domenicotti, Cinzia; Traverso, N.; Marinari, Umberto Maria; Pronzato, Maria Adelaide; Nitti, Mariapaola.
In: Oxidative Medicine and Cellular Longevity, Vol. 2016, 9348651, 2016.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - RAGE Expression and ROS Generation in Neurons
T2 - Differentiation versus Damage
AU - Piras, S.
AU - Furfaro, Annalisa
AU - Domenicotti, Cinzia
AU - Traverso, N.
AU - Marinari, Umberto Maria
AU - Pronzato, Maria Adelaide
AU - Nitti, Mariapaola
PY - 2016
Y1 - 2016
N2 - RAGE is a multiligand receptor able to bind advanced glycation end-products (AGEs), amphoterin, calgranulins, and amyloid-beta peptides, identified in many tissues and cells, including neurons. RAGE stimulation induces the generation of reactive oxygen species (ROS) mainly through the activity of NADPH oxidases. In neuronal cells, RAGE-induced ROS generation is able to favor cell survival and differentiation or to induce death through the imbalance of redox state. The dual nature of RAGE signaling in neurons depends not only on the intensity of RAGE activation but also on the ability of RAGE-bearing cells to adapt to ROS generation. In this review we highlight these aspects of RAGE signaling regulation in neuronal cells.
AB - RAGE is a multiligand receptor able to bind advanced glycation end-products (AGEs), amphoterin, calgranulins, and amyloid-beta peptides, identified in many tissues and cells, including neurons. RAGE stimulation induces the generation of reactive oxygen species (ROS) mainly through the activity of NADPH oxidases. In neuronal cells, RAGE-induced ROS generation is able to favor cell survival and differentiation or to induce death through the imbalance of redox state. The dual nature of RAGE signaling in neurons depends not only on the intensity of RAGE activation but also on the ability of RAGE-bearing cells to adapt to ROS generation. In this review we highlight these aspects of RAGE signaling regulation in neuronal cells.
UR - http://www.scopus.com/inward/record.url?scp=84975104902&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84975104902&partnerID=8YFLogxK
U2 - 10.1155/2016/9348651
DO - 10.1155/2016/9348651
M3 - Review article
C2 - 27313835
AN - SCOPUS:84975104902
VL - 2016
JO - Oxidative Medicine and Cellular Longevity
JF - Oxidative Medicine and Cellular Longevity
SN - 1942-0900
M1 - 9348651
ER -