Rage gene polymorphism in heart failure patients with and without angiographic evidence of significant coronary atherosclerosis

Colomba Falcone, S. Bozzini, B. Matrone, A. Colonna, R. Falcone, M. Calcagnino, G. Pelissero

Research output: Contribution to journalArticlepeer-review

Abstract

Heart failure (HF) is a multifactorial disorder in which clinical, environmental and genetic components take part. For this reason it is possible that common gene variants could affect development, progression and response to pharmacological therapy. In recent years the role of AGEs in the pathogenesis of cardiovascular diseases has become recognized but little is known about the role of the AGE-RAGE system in heart failure. The aim of the present study was to identify possible relationship between -374 T/A RAGE gene polymorphism with heart failure. The population in this study consists of 386 subjects with HF, selected according to the presence of depressed Left Ventricular Ejection Fraction (LVEF)

Original languageEnglish
Pages (from-to)199-206
Number of pages8
JournalInternational Journal of Immunopathology and Pharmacology
Volume26
Issue number1
Publication statusPublished - Jan 2013

Keywords

  • Coronary artery disease
  • Heart failure
  • RAGE polymorphism

ASJC Scopus subject areas

  • Pharmacology
  • Immunology
  • Immunology and Allergy

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