Abstract
Heart failure (HF) is a multifactorial disorder in which clinical, environmental and genetic components take part. For this reason it is possible that common gene variants could affect development, progression and response to pharmacological therapy. In recent years the role of AGEs in the pathogenesis of cardiovascular diseases has become recognized but little is known about the role of the AGE-RAGE system in heart failure. The aim of the present study was to identify possible relationship between -374 T/A RAGE gene polymorphism with heart failure. The population in this study consists of 386 subjects with HF, selected according to the presence of depressed Left Ventricular Ejection Fraction (LVEF)
Original language | English |
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Pages (from-to) | 199-206 |
Number of pages | 8 |
Journal | International Journal of Immunopathology and Pharmacology |
Volume | 26 |
Issue number | 1 |
Publication status | Published - Jan 2013 |
Keywords
- Coronary artery disease
- Heart failure
- RAGE polymorphism
ASJC Scopus subject areas
- Pharmacology
- Immunology
- Immunology and Allergy