Rage gene polymorphism in heart failure patients with and without angiographic evidence of significant coronary atherosclerosis

Colomba Falcone; S. Bozzini; B. Matrone; A. Colonna; R. Falcone; M. Calcagnino; G. Pelissero

Rage gene polymorphism in heart failure patients with and without angiographic evidence of significant coronary atherosclerosis

Colomba Falcone, S. Bozzini, B. Matrone, A. Colonna, R. Falcone, M. Calcagnino, G. Pelissero

IRCCS Policlinico San Donato

Research output: Contribution to journal › Article › peer-review

Abstract

Heart failure (HF) is a multifactorial disorder in which clinical, environmental and genetic components take part. For this reason it is possible that common gene variants could affect development, progression and response to pharmacological therapy. In recent years the role of AGEs in the pathogenesis of cardiovascular diseases has become recognized but little is known about the role of the AGE-RAGE system in heart failure. The aim of the present study was to identify possible relationship between -374 T/A RAGE gene polymorphism with heart failure. The population in this study consists of 386 subjects with HF, selected according to the presence of depressed Left Ventricular Ejection Fraction (LVEF)

Original language	English
Pages (from-to)	199-206
Number of pages	8
Journal	International Journal of Immunopathology and Pharmacology
Volume	26
Issue number	1
Publication status	Published - Jan 2013

Keywords

Coronary artery disease
Heart failure
RAGE polymorphism

ASJC Scopus subject areas

Pharmacology
Immunology
Immunology and Allergy

Cite this

Rage gene polymorphism in heart failure patients with and without angiographic evidence of significant coronary atherosclerosis. / Falcone, Colomba; Bozzini, S.; Matrone, B.; Colonna, A.; Falcone, R.; Calcagnino, M.; Pelissero, G.

In: International Journal of Immunopathology and Pharmacology, Vol. 26, No. 1, 01.2013, p. 199-206.

Research output: Contribution to journal › Article › peer-review

@article{ede957e37c2f4ebda59db624f351302c,

title = "Rage gene polymorphism in heart failure patients with and without angiographic evidence of significant coronary atherosclerosis",

abstract = "Heart failure (HF) is a multifactorial disorder in which clinical, environmental and genetic components take part. For this reason it is possible that common gene variants could affect development, progression and response to pharmacological therapy. In recent years the role of AGEs in the pathogenesis of cardiovascular diseases has become recognized but little is known about the role of the AGE-RAGE system in heart failure. The aim of the present study was to identify possible relationship between -374 T/A RAGE gene polymorphism with heart failure. The population in this study consists of 386 subjects with HF, selected according to the presence of depressed Left Ventricular Ejection Fraction (LVEF) ",

keywords = "Coronary artery disease, Heart failure, RAGE polymorphism",

author = "Colomba Falcone and S. Bozzini and B. Matrone and A. Colonna and R. Falcone and M. Calcagnino and G. Pelissero",

year = "2013",

month = jan,

language = "English",

volume = "26",

pages = "199--206",

journal = "International Journal of Immunopathology and Pharmacology",

issn = "0394-6320",

publisher = "Biomedical Research Press s.a.s.",

number = "1",

}

TY - JOUR

T1 - Rage gene polymorphism in heart failure patients with and without angiographic evidence of significant coronary atherosclerosis

AU - Falcone, Colomba

AU - Bozzini, S.

AU - Matrone, B.

AU - Colonna, A.

AU - Falcone, R.

AU - Calcagnino, M.

AU - Pelissero, G.

PY - 2013/1

Y1 - 2013/1

N2 - Heart failure (HF) is a multifactorial disorder in which clinical, environmental and genetic components take part. For this reason it is possible that common gene variants could affect development, progression and response to pharmacological therapy. In recent years the role of AGEs in the pathogenesis of cardiovascular diseases has become recognized but little is known about the role of the AGE-RAGE system in heart failure. The aim of the present study was to identify possible relationship between -374 T/A RAGE gene polymorphism with heart failure. The population in this study consists of 386 subjects with HF, selected according to the presence of depressed Left Ventricular Ejection Fraction (LVEF)

AB - Heart failure (HF) is a multifactorial disorder in which clinical, environmental and genetic components take part. For this reason it is possible that common gene variants could affect development, progression and response to pharmacological therapy. In recent years the role of AGEs in the pathogenesis of cardiovascular diseases has become recognized but little is known about the role of the AGE-RAGE system in heart failure. The aim of the present study was to identify possible relationship between -374 T/A RAGE gene polymorphism with heart failure. The population in this study consists of 386 subjects with HF, selected according to the presence of depressed Left Ventricular Ejection Fraction (LVEF)

KW - Coronary artery disease

KW - Heart failure

KW - RAGE polymorphism

UR - http://www.scopus.com/inward/record.url?scp=84881221381&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84881221381&partnerID=8YFLogxK

M3 - Article

C2 - 23527722

AN - SCOPUS:84881221381

VL - 26

SP - 199

EP - 206

JO - International Journal of Immunopathology and Pharmacology

JF - International Journal of Immunopathology and Pharmacology

SN - 0394-6320

IS - 1

ER -

Rage gene polymorphism in heart failure patients with and without angiographic evidence of significant coronary atherosclerosis

Abstract

Keywords

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this