RAGE is a multiligand receptor of the immunoglobulin superfamily: Implications for homeostasis and chronic disease

L. G. Bucciarelli; T. Wendt; L. Rong; E. Lalla; M. A. Hofmann; M. T. Goova; A. Taguchi; S. F. Yan; S. D. Yan; D. M. Stern; A. M. Schmidt

doi:10.1007/s00018-002-8491-x

RAGE is a multiligand receptor of the immunoglobulin superfamily: Implications for homeostasis and chronic disease

L. G. Bucciarelli, T. Wendt, L. Rong, E. Lalla, M. A. Hofmann, M. T. Goova, A. Taguchi, S. F. Yan, S. D. Yan, D. M. Stern, A. M. Schmidt

IRCCS Multimedica

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Abstract

Receptor for AGE (RAGE) is a member of the immunoglobulin superfamily that engages distinct classes of ligands. The biology of RAGE is driven by the settings in which these ligands accumulate, such as diabetes, inflammation, neurodegenerative disorders and tumors. In this review, we discuss the context of each of these classes ofligands, including advance glycation end-products, amyloid β peptide and the family of β sheet fibrils, S100/calgranulins and amphoterin. Implications for the role of these ligands interacting with RAGE in homeostasis and disease will be considered.

Original language	English
Pages (from-to)	1117-1128
Number of pages	12
Journal	Cellular and Molecular Life Sciences
Volume	59
Issue number	7
DOIs	https://doi.org/10.1007/s00018-002-8491-x
Publication status	Published - Jul 2002

Keywords

Atherosclerosis
Cancer
Diabetes
Immunoglobulin
Inflammation
Receptor
Superfamily
Vasculopathy

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Cell Biology

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Bucciarelli, L. G., Wendt, T., Rong, L., Lalla, E., Hofmann, M. A., Goova, M. T., Taguchi, A., Yan, S. F., Yan, S. D., Stern, D. M., & Schmidt, A. M. (2002). RAGE is a multiligand receptor of the immunoglobulin superfamily: Implications for homeostasis and chronic disease. Cellular and Molecular Life Sciences, 59(7), 1117-1128. https://doi.org/10.1007/s00018-002-8491-x

RAGE is a multiligand receptor of the immunoglobulin superfamily : Implications for homeostasis and chronic disease. / Bucciarelli, L. G.; Wendt, T.; Rong, L.; Lalla, E.; Hofmann, M. A.; Goova, M. T.; Taguchi, A.; Yan, S. F.; Yan, S. D.; Stern, D. M.; Schmidt, A. M.

In: Cellular and Molecular Life Sciences, Vol. 59, No. 7, 07.2002, p. 1117-1128.

Research output: Contribution to journal › Article › peer-review

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AU - Rong, L.

AU - Lalla, E.

AU - Hofmann, M. A.

AU - Goova, M. T.

AU - Taguchi, A.

AU - Yan, S. F.

AU - Yan, S. D.

AU - Stern, D. M.

AU - Schmidt, A. M.

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RAGE is a multiligand receptor of the immunoglobulin superfamily: Implications for homeostasis and chronic disease

Abstract

Keywords

ASJC Scopus subject areas

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