RAGE is a multiligand receptor of the immunoglobulin superfamily: Implications for homeostasis and chronic disease

L. G. Bucciarelli, T. Wendt, L. Rong, E. Lalla, M. A. Hofmann, M. T. Goova, A. Taguchi, S. F. Yan, S. D. Yan, D. M. Stern, A. M. Schmidt

Research output: Contribution to journalArticlepeer-review

Abstract

Receptor for AGE (RAGE) is a member of the immunoglobulin superfamily that engages distinct classes of ligands. The biology of RAGE is driven by the settings in which these ligands accumulate, such as diabetes, inflammation, neurodegenerative disorders and tumors. In this review, we discuss the context of each of these classes ofligands, including advance glycation end-products, amyloid β peptide and the family of β sheet fibrils, S100/calgranulins and amphoterin. Implications for the role of these ligands interacting with RAGE in homeostasis and disease will be considered.

Original languageEnglish
Pages (from-to)1117-1128
Number of pages12
JournalCellular and Molecular Life Sciences
Volume59
Issue number7
DOIs
Publication statusPublished - Jul 2002

Keywords

  • Atherosclerosis
  • Cancer
  • Diabetes
  • Immunoglobulin
  • Inflammation
  • Receptor
  • Superfamily
  • Vasculopathy

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cell Biology

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