RAGs and BUGS: An alliance for autoimmunity

Research output: Contribution to journalArticle

Abstract

Hypomorphic Rag mutations in humans cause Omenn Syndrome (OS) a severe immunodeficiency associated with autoimmune-like manifestations mediated by oligoclonal activated T and B cells. The clinical and immunological spectrum of OS presentation is extremely broad. However, the role played by environmental triggers in the disease pathogenesis remains largely unknown. We have recently shown in a murine model that gut microbiota has a substantial role in determining the distinctive immune dysregulation of OS. Here, we describe how dysbiosis and loss of T cell tolerance to commensals influence the expression of autoimmunity at the barrier site and beyond, and the disease hallmark hyper-IgE. We discuss how commensal antigens and gut-derived pathogenic T cells could potentially modulate skin immunity to determine cutaneous degenerations in OS. These mechanisms may have broader implications for a deeper understanding of the role of gut microbes in influencing barriers integrity and host physiology.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalGut Microbes
DOIs
Publication statusAccepted/In press - Sep 11 2016

Keywords

  • commensal bacteria
  • dysbiosis
  • hyperIgE
  • IgA deficiency
  • immunodeficiency
  • RAG
  • T and B cell autoimmunity

ASJC Scopus subject areas

  • Gastroenterology
  • Infectious Diseases
  • Microbiology (medical)
  • Microbiology

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