Raised serum β2 microglobulin levels in different stages of human immunodeficiency virus infection

F. Franzetti, G. Cavalli, C. U. Foppa, M. C. Amprimo, P. Gaido, A. Lazzarin

Research output: Contribution to journalArticlepeer-review

Abstract

Serum β2 microglobulin (β2-M) levels were determined in patients with Acquired Immunodeficiency Syndrome (AIDS), AIDS Related Complex (ARC), Persistent Generalized Lymphadenopathy (PGL), healthy intravenous drug addicts (IVDA) and heterosexual controls. Seventy-eight out of 79 AIDS patients (98.7%) exhibited elevated β2-M levels. High levels of β2-M were also found in 83 of 100 (83%) of PGL/ARC patients and in 24 of 56 (42.8%) healthy IVDA. Patients with AIDS had significantly higher mean β2-M levels when compared with all other groups. The mean levels of PGL/ARC patients were significantly higher than those of healthy IVDA and the mean levels for healthy IVDA significantly differ from those of the heterosexual controls. After 2-24 months of follow up three out of four PGL/ARC patients whose serum β2-M was greater than 8.0 mg/l developed AIDS.

Original languageEnglish
Pages (from-to)133-137
Number of pages5
JournalJournal of Clinical and Laboratory Immunology
Volume27
Issue number3
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Immunology

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