Raltegravir, maraviroc, etravirine: An effective protease inhibitor and nucleoside reverse transcriptase inhibitor-sparing regimen for salvage therapy in HIV-infected patients with triple-class experience

Silvia Nozza; Laura Galli; Francesca Visco; Alessandro Soria; Filippo Canducci; Stefania Salpietro; Nicola Gianotti; Alba Bigoloni; Liviana Della Torre; Giuseppe Tambussi; Adriano Lazzarin; Antonella Castagna

doi:10.1097/QAD.0b013e3283372d76

Raltegravir, maraviroc, etravirine: An effective protease inhibitor and nucleoside reverse transcriptase inhibitor-sparing regimen for salvage therapy in HIV-infected patients with triple-class experience

Silvia Nozza, Laura Galli, Francesca Visco, Alessandro Soria, Filippo Canducci, Stefania Salpietro, Nicola Gianotti, Alba Bigoloni, Liviana Della Torre, Giuseppe Tambussi, Adriano Lazzarin, Antonella Castagna

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

We prospectively evaluated 28 triple-class experienced HIV-1-infected patients harbouring R5 virus, who received maraviroc, raltegravir and etravirine. By on-treatment analysis, 26 (92%) had less than 50 copies HIV-RNA/ml at week 48. The median (interquartile range) 48-week increase in CD4 cell counts was 267 (136-355) cells/μl. Three serious adverse events occurred: one recurrence of mycobacterial spondylodiscitis, one anal cancer, one Hodgkin lymphoma. Although long-term safety needs further study, this protease inhibitor and nucleoside analogue-sparing regimen showed sustained efficacy.

Original language	English
Pages (from-to)	924-928
Number of pages	5
Journal	AIDS (London, England)
Volume	24
Issue number	6
DOIs	https://doi.org/10.1097/QAD.0b013e3283372d76
Publication status	Published - Mar 2010

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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Nozza, S., Galli, L., Visco, F., Soria, A., Canducci, F., Salpietro, S., Gianotti, N., Bigoloni, A., Torre, L. D., Tambussi, G., Lazzarin, A., & Castagna, A. (2010). Raltegravir, maraviroc, etravirine: An effective protease inhibitor and nucleoside reverse transcriptase inhibitor-sparing regimen for salvage therapy in HIV-infected patients with triple-class experience. AIDS (London, England), 24(6), 924-928. https://doi.org/10.1097/QAD.0b013e3283372d76

Raltegravir, maraviroc, etravirine : An effective protease inhibitor and nucleoside reverse transcriptase inhibitor-sparing regimen for salvage therapy in HIV-infected patients with triple-class experience. / Nozza, Silvia ; Galli, Laura; Visco, Francesca; Soria, Alessandro; Canducci, Filippo; Salpietro, Stefania; Gianotti, Nicola; Bigoloni, Alba; Torre, Liviana Della; Tambussi, Giuseppe; Lazzarin, Adriano; Castagna, Antonella.

In: AIDS (London, England), Vol. 24, No. 6, 03.2010, p. 924-928.

Research output: Contribution to journal › Article › peer-review

Nozza, S , Galli, L, Visco, F, Soria, A, Canducci, F, Salpietro, S, Gianotti, N, Bigoloni, A, Torre, LD, Tambussi, G, Lazzarin, A & Castagna, A 2010, 'Raltegravir, maraviroc, etravirine: An effective protease inhibitor and nucleoside reverse transcriptase inhibitor-sparing regimen for salvage therapy in HIV-infected patients with triple-class experience', AIDS (London, England), vol. 24, no. 6, pp. 924-928. https://doi.org/10.1097/QAD.0b013e3283372d76

Nozza, Silvia ; Galli, Laura ; Visco, Francesca ; Soria, Alessandro ; Canducci, Filippo ; Salpietro, Stefania ; Gianotti, Nicola ; Bigoloni, Alba ; Torre, Liviana Della ; Tambussi, Giuseppe ; Lazzarin, Adriano ; Castagna, Antonella. / Raltegravir, maraviroc, etravirine : An effective protease inhibitor and nucleoside reverse transcriptase inhibitor-sparing regimen for salvage therapy in HIV-infected patients with triple-class experience. In: AIDS (London, England). 2010 ; Vol. 24, No. 6. pp. 924-928.

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abstract = "We prospectively evaluated 28 triple-class experienced HIV-1-infected patients harbouring R5 virus, who received maraviroc, raltegravir and etravirine. By on-treatment analysis, 26 (92%) had less than 50 copies HIV-RNA/ml at week 48. The median (interquartile range) 48-week increase in CD4 cell counts was 267 (136-355) cells/μl. Three serious adverse events occurred: one recurrence of mycobacterial spondylodiscitis, one anal cancer, one Hodgkin lymphoma. Although long-term safety needs further study, this protease inhibitor and nucleoside analogue-sparing regimen showed sustained efficacy.",

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AU - Canducci, Filippo

AU - Salpietro, Stefania

AU - Gianotti, Nicola

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AB - We prospectively evaluated 28 triple-class experienced HIV-1-infected patients harbouring R5 virus, who received maraviroc, raltegravir and etravirine. By on-treatment analysis, 26 (92%) had less than 50 copies HIV-RNA/ml at week 48. The median (interquartile range) 48-week increase in CD4 cell counts was 267 (136-355) cells/μl. Three serious adverse events occurred: one recurrence of mycobacterial spondylodiscitis, one anal cancer, one Hodgkin lymphoma. Although long-term safety needs further study, this protease inhibitor and nucleoside analogue-sparing regimen showed sustained efficacy.

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Raltegravir, maraviroc, etravirine: An effective protease inhibitor and nucleoside reverse transcriptase inhibitor-sparing regimen for salvage therapy in HIV-infected patients with triple-class experience

Abstract

ASJC Scopus subject areas

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