Raltegravir plasma concentrations in treatment-experienced patients receiving salvage regimens based on raltegravir with and without maraviroc coadministration

Silvia Baroncelli, Paola Villani, Liliana E. Weimer, Nicoletta Ladisa, Daniela Francisci, Chiara Tommasi, Vincenzo Vullo, Roberta Preziosi, Stefania Cicalini, Maria Cusato, Clementina M. Galluzzo, Marco Floridia, Mario Regazzi

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Raltegravir and maraviroc represent new, important resources for HIV-infected patients with intolerance or resistance to other antiretroviral agents. The safety and efficacy of both drugs have been investigated, but there is no information on possible pharmacokinetic interactions between these 2 drugs in clinical practice. OBJECTIVE: To evaluate raltegravir plasma concentrations in heavily treatmentexperienced patients receiving salvage regimens and explore, in a preliminary assessment, the potential influence of maraviroc coadministration and other cofactors on raltegravir trough concentrations (Ctrough). METHODS: Fifty-four HIV-infected patients with triple class (nucleoside reverse transcriptase inhibitor, nonnucleoside reverse transcriptase inhibitor, protease inhibitor) treatment experience starting raltegravir 400 mg twice daily, with (n = 11) or without (n = 43) concomitant maraviroc 300 mg twice daily, were evaluated. All regimens included at least 3 drugs of at least 2 different classes. Raltegravir plasma C trough, after at least 1 month of treatment, were analyzed to compare groups of patients taking raltegravir only and raltegravir plus maraviroc. Immunovirological (CD4, HIV-RNA) and clinical data after 6 months of treatment were also collected and described. RESULTS: Raltegravir plasma C trough showed a large variability (range 0.02 μg/mL) raltegravir concentrations were observed in all patients receiving raltegravir + maraviroc and in 74% of patients receiving raltegravir alone (p = 0.060). After 6 months of treatment, the 2 groups had similar clinical, virologic, and immunologic conditions. CONCLUSIONS: Coadministration of maraviroc does not seem to have any relevant effects on raltegravir plasma C trough in heavily treatment-experienced patients receiving salvage regimens. Further studies should evaluate the potential additional benefits of maraviroc coadministration in terms of virologic and immunologic response.

Original languageEnglish
Pages (from-to)838-843
Number of pages6
JournalAnnals of Pharmacotherapy
Volume44
Issue number5
DOIs
Publication statusPublished - May 2010

Keywords

  • Drug interactions
  • Maraviroc
  • Plasma drug concentrations
  • Raltegravir
  • Salvage regimens

ASJC Scopus subject areas

  • Pharmacology (medical)

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  • Cite this

    Baroncelli, S., Villani, P., Weimer, L. E., Ladisa, N., Francisci, D., Tommasi, C., Vullo, V., Preziosi, R., Cicalini, S., Cusato, M., Galluzzo, C. M., Floridia, M., & Regazzi, M. (2010). Raltegravir plasma concentrations in treatment-experienced patients receiving salvage regimens based on raltegravir with and without maraviroc coadministration. Annals of Pharmacotherapy, 44(5), 838-843. https://doi.org/10.1345/aph.1M688