Randomised study of systematic lymphadenectomy in patients with epithelial ovarian cancer macroscopically confined to the pelvis

A. Maggioni, P. Benedetti Panici, T. Dell'Anna, F. Landoni, A. Lissoni, A. Pellegrino, R. S. Rossi, S. Chiari, E. Campagnutta, S. Greggi, R. Angioli, N. Manci, M. Calcagno, G. Scambia, R. Fossati, I. Floriani, V. Torri, R. Grassi, C. Mangioni

Research output: Contribution to journalArticlepeer-review

Abstract

No randomised trials have addressed the value of systematic aortic and pelvic lymphadenectomy (SL) in ovarian cancer macroscopically confined to the pelvis. This study was conducted to investigate the role of SL compared with lymph nodes sampling (CONTROL) in the management of early stage ovarian cancer. A total of 268 eligible patients with macroscopically intrapelvic ovarian carcinoma were randomised to SL (N = 138) or CONTROL (N = 130). The primary objective was to compare the proportion of patients with retroperitoneal nodal involvement between the two groups. Median operating time was longer and more patients required blood transfusions in the SL arm than the CONTROL arm (240 vs 150 min, P

Original languageEnglish
Pages (from-to)699-704
Number of pages6
JournalBritish Journal of Cancer
Volume95
Issue number6
DOIs
Publication statusPublished - Sep 18 2006

Keywords

  • Lymphadenectomy
  • Ovarian carcinoma
  • Randomised clinical trial
  • Surgery

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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