Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6105 individuals with previous stroke or transient ischaemic attack

S. MacMahon; B. Neal; C. Tzourio; A. Rodgers; M. Woodward; J. Cutler; C. Anderson; J. Chalmers; T. Ohkubo; M. G. Bouser; S. Davis; G. Donnan; L. Hansson; S. Harrap; K. R. Lees; L. Liu; G. Mancia; B. Neal; T. Omae; J. Reid; A. Rodgers; R. Sega; A. Terent; C. Tzourio; C. Warlow; M. Woodward; N. Anderson; C. Bladin; B. Chambers; G. Gordon; N. Sharpe; R. Collins; P. Sandercock; J. Simes; P. Sleight; A. Brnabic; S. Colman; L. Francis; A. Lee; L. Gong; M. G. Bousser; T. Yamaguchi; K. R. Lees; F. William; Q. Deng; D. X. Hu; W. Wang; A. L. Wu; L. Y. Ma; Z. Y. Tao; V. Biousse; K. Berthet; L. Ben Slamia; C. Le Denmat; S. Crespi; G. Foglia; C. Fujimoto; S. Matsumura; K. Marttala; M. Pettersson; M. Safwenberg; J. Fenton; Y. McIlvenna; R. Currie; H. Bartram; J. Briad; A. Clague; Y. Cleverly; M. Cosson; A. Culpan; D. Douglas; S. Flett; B. Gray; T. Holloway; A. Milne; R. Prasad; Y. Ratnasabapathy; A. Santos; M. Wills; T. Agnew; N. Chapman; N. Lewis; B. Mullane

doi:10.1016/S0140-6736(01)06178-5

Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6105 individuals with previous stroke or transient ischaemic attack

S. MacMahon, B. Neal, C. Tzourio, A. Rodgers, M. Woodward, J. Cutler, C. Anderson, J. Chalmers, T. Ohkubo, M. G. Bouser, S. Davis, G. Donnan, L. Hansson, S. Harrap, K. R. Lees, L. Liu, G. Mancia, B. Neal, T. Omae, J. ReidA. Rodgers, R. Sega, A. Terent, C. Tzourio, C. Warlow, M. Woodward, N. Anderson, C. Bladin, B. Chambers, G. Gordon, N. Sharpe, R. Collins, P. Sandercock, J. Simes, P. Sleight, A. Brnabic, S. Colman, L. Francis, A. Lee, L. Gong, M. G. Bousser, T. Yamaguchi, K. R. Lees, F. William, Q. Deng, D. X. Hu, W. Wang, A. L. Wu, L. Y. Ma, Z. Y. Tao, V. Biousse, K. Berthet, L. Ben Slamia, C. Le Denmat, S. Crespi, G. Foglia, C. Fujimoto, S. Matsumura, K. Marttala, M. Pettersson, M. Safwenberg, J. Fenton, Y. McIlvenna, R. Currie, H. Bartram, J. Briad, A. Clague, Y. Cleverly, M. Cosson, A. Culpan, D. Douglas, S. Flett, B. Gray, T. Holloway, A. Milne, R. Prasad, Y. Ratnasabapathy, A. Santos, M. Wills, T. Agnew, N. Chapman, N. Lewis, B. Mullane

Fondazione Istituto Auxologico Italiano

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Blood pressure is a determinant of the risk of stroke among both hypertensive and non-hypertensive individuals with cerebrovascular disease. However, there is uncertainty about the efficacy and safety of blood-pressure-lowering treatments for many such patients. The perindopril protection against recurrent stroke study (PROGRESS) was designed to determine the effects of a blood-pressure-lowering regimen in hypertensive and non-hypertensive patients with a history of stroke or transient ischaemic attack. Methods: 6105 individuals from 172 centres in Asia, Australasia, and Europe were randomly assigned active treatment (n=3051) or placebo (n=3054). Active treatment comprised a flexible regimen based on the angiotensin-converting-enzyme inhibitor perindopril (4 mg daily), with the addition of the diuretic indapamide at the discretion of treating physicians. The primary outcome was total stroke (fatal or non-fatal). Analysis was by intention to treat. Findings: Over 4 years of follow up, active treatment reduced blood pressure by 9/4 mm Hg. 307 (10%) individuals assigned active treatment suffered a stroke, compared with 420 (14%) assigned placebo (relative risk reduction 28% [95% CI 17-38], p

Original language	English
Pages (from-to)	1033-1041
Number of pages	9
Journal	Lancet
Volume	358
Issue number	9287
DOIs	https://doi.org/10.1016/S0140-6736(01)06178-5
Publication status	Published - Sep 29 2001

ASJC Scopus subject areas

Medicine(all)

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10.1016/S0140-6736(01)06178-5

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MacMahon, S., Neal, B., Tzourio, C., Rodgers, A., Woodward, M., Cutler, J., Anderson, C., Chalmers, J., Ohkubo, T., Bouser, M. G., Davis, S., Donnan, G., Hansson, L., Harrap, S., Lees, K. R., Liu, L., Mancia, G., Neal, B., Omae, T., ... Mullane, B. (2001). Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6105 individuals with previous stroke or transient ischaemic attack. Lancet, 358(9287), 1033-1041. https://doi.org/10.1016/S0140-6736(01)06178-5

Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6105 individuals with previous stroke or transient ischaemic attack. / MacMahon, S.; Neal, B.; Tzourio, C.; Rodgers, A.; Woodward, M.; Cutler, J.; Anderson, C.; Chalmers, J.; Ohkubo, T.; Bouser, M. G.; Davis, S.; Donnan, G.; Hansson, L.; Harrap, S.; Lees, K. R.; Liu, L.; Mancia, G.; Neal, B.; Omae, T.; Reid, J.; Rodgers, A.; Sega, R.; Terent, A.; Tzourio, C.; Warlow, C.; Woodward, M.; Anderson, N.; Bladin, C.; Chambers, B.; Gordon, G.; Sharpe, N.; Collins, R.; Sandercock, P.; Simes, J.; Sleight, P.; Brnabic, A.; Colman, S.; Francis, L.; Lee, A.; Gong, L.; Bousser, M. G.; Yamaguchi, T.; Lees, K. R.; William, F.; Deng, Q.; Hu, D. X.; Wang, W.; Wu, A. L.; Ma, L. Y.; Tao, Z. Y.; Biousse, V.; Berthet, K.; Ben Slamia, L.; Le Denmat, C.; Crespi, S.; Foglia, G.; Fujimoto, C.; Matsumura, S.; Marttala, K.; Pettersson, M.; Safwenberg, M.; Fenton, J.; McIlvenna, Y.; Currie, R.; Bartram, H.; Briad, J.; Clague, A.; Cleverly, Y.; Cosson, M.; Culpan, A.; Douglas, D.; Flett, S.; Gray, B.; Holloway, T.; Milne, A.; Prasad, R.; Ratnasabapathy, Y.; Santos, A.; Wills, M.; Agnew, T.; Chapman, N.; Lewis, N.; Mullane, B.

In: Lancet, Vol. 358, No. 9287, 29.09.2001, p. 1033-1041.

Research output: Contribution to journal › Article › peer-review

MacMahon, S, Neal, B, Tzourio, C, Rodgers, A, Woodward, M, Cutler, J, Anderson, C, Chalmers, J, Ohkubo, T, Bouser, MG, Davis, S, Donnan, G, Hansson, L, Harrap, S, Lees, KR, Liu, L, Mancia, G, Neal, B, Omae, T, Reid, J, Rodgers, A, Sega, R, Terent, A, Tzourio, C, Warlow, C, Woodward, M, Anderson, N, Bladin, C, Chambers, B, Gordon, G, Sharpe, N, Collins, R, Sandercock, P, Simes, J, Sleight, P, Brnabic, A, Colman, S, Francis, L, Lee, A, Gong, L, Bousser, MG, Yamaguchi, T, Lees, KR, William, F, Deng, Q, Hu, DX, Wang, W, Wu, AL, Ma, LY, Tao, ZY, Biousse, V, Berthet, K, Ben Slamia, L, Le Denmat, C, Crespi, S, Foglia, G, Fujimoto, C, Matsumura, S, Marttala, K, Pettersson, M, Safwenberg, M, Fenton, J, McIlvenna, Y, Currie, R, Bartram, H, Briad, J, Clague, A, Cleverly, Y, Cosson, M, Culpan, A, Douglas, D, Flett, S, Gray, B, Holloway, T, Milne, A, Prasad, R, Ratnasabapathy, Y, Santos, A, Wills, M, Agnew, T, Chapman, N, Lewis, N & Mullane, B 2001, 'Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6105 individuals with previous stroke or transient ischaemic attack', Lancet, vol. 358, no. 9287, pp. 1033-1041. https://doi.org/10.1016/S0140-6736(01)06178-5

MacMahon, S. ; Neal, B. ; Tzourio, C. ; Rodgers, A. ; Woodward, M. ; Cutler, J. ; Anderson, C. ; Chalmers, J. ; Ohkubo, T. ; Bouser, M. G. ; Davis, S. ; Donnan, G. ; Hansson, L. ; Harrap, S. ; Lees, K. R. ; Liu, L. ; Mancia, G. ; Neal, B. ; Omae, T. ; Reid, J. ; Rodgers, A. ; Sega, R. ; Terent, A. ; Tzourio, C. ; Warlow, C. ; Woodward, M. ; Anderson, N. ; Bladin, C. ; Chambers, B. ; Gordon, G. ; Sharpe, N. ; Collins, R. ; Sandercock, P. ; Simes, J. ; Sleight, P. ; Brnabic, A. ; Colman, S. ; Francis, L. ; Lee, A. ; Gong, L. ; Bousser, M. G. ; Yamaguchi, T. ; Lees, K. R. ; William, F. ; Deng, Q. ; Hu, D. X. ; Wang, W. ; Wu, A. L. ; Ma, L. Y. ; Tao, Z. Y. ; Biousse, V. ; Berthet, K. ; Ben Slamia, L. ; Le Denmat, C. ; Crespi, S. ; Foglia, G. ; Fujimoto, C. ; Matsumura, S. ; Marttala, K. ; Pettersson, M. ; Safwenberg, M. ; Fenton, J. ; McIlvenna, Y. ; Currie, R. ; Bartram, H. ; Briad, J. ; Clague, A. ; Cleverly, Y. ; Cosson, M. ; Culpan, A. ; Douglas, D. ; Flett, S. ; Gray, B. ; Holloway, T. ; Milne, A. ; Prasad, R. ; Ratnasabapathy, Y. ; Santos, A. ; Wills, M. ; Agnew, T. ; Chapman, N. ; Lewis, N. ; Mullane, B. / Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6105 individuals with previous stroke or transient ischaemic attack. In: Lancet. 2001 ; Vol. 358, No. 9287. pp. 1033-1041.

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title = "Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6105 individuals with previous stroke or transient ischaemic attack",

abstract = "Background: Blood pressure is a determinant of the risk of stroke among both hypertensive and non-hypertensive individuals with cerebrovascular disease. However, there is uncertainty about the efficacy and safety of blood-pressure-lowering treatments for many such patients. The perindopril protection against recurrent stroke study (PROGRESS) was designed to determine the effects of a blood-pressure-lowering regimen in hypertensive and non-hypertensive patients with a history of stroke or transient ischaemic attack. Methods: 6105 individuals from 172 centres in Asia, Australasia, and Europe were randomly assigned active treatment (n=3051) or placebo (n=3054). Active treatment comprised a flexible regimen based on the angiotensin-converting-enzyme inhibitor perindopril (4 mg daily), with the addition of the diuretic indapamide at the discretion of treating physicians. The primary outcome was total stroke (fatal or non-fatal). Analysis was by intention to treat. Findings: Over 4 years of follow up, active treatment reduced blood pressure by 9/4 mm Hg. 307 (10%) individuals assigned active treatment suffered a stroke, compared with 420 (14%) assigned placebo (relative risk reduction 28% [95% CI 17-38], p",

author = "S. MacMahon and B. Neal and C. Tzourio and A. Rodgers and M. Woodward and J. Cutler and C. Anderson and J. Chalmers and T. Ohkubo and Bouser, {M. G.} and S. Davis and G. Donnan and L. Hansson and S. Harrap and Lees, {K. R.} and L. Liu and G. Mancia and B. Neal and T. Omae and J. Reid and A. Rodgers and R. Sega and A. Terent and C. Tzourio and C. Warlow and M. Woodward and N. Anderson and C. Bladin and B. Chambers and G. Gordon and N. Sharpe and R. Collins and P. Sandercock and J. Simes and P. Sleight and A. Brnabic and S. Colman and L. Francis and A. Lee and L. Gong and Bousser, {M. G.} and T. Yamaguchi and Lees, {K. R.} and F. William and Q. Deng and Hu, {D. X.} and W. Wang and Wu, {A. L.} and Ma, {L. Y.} and Tao, {Z. Y.} and V. Biousse and K. Berthet and {Ben Slamia}, L. and {Le Denmat}, C. and S. Crespi and G. Foglia and C. Fujimoto and S. Matsumura and K. Marttala and M. Pettersson and M. Safwenberg and J. Fenton and Y. McIlvenna and R. Currie and H. Bartram and J. Briad and A. Clague and Y. Cleverly and M. Cosson and A. Culpan and D. Douglas and S. Flett and B. Gray and T. Holloway and A. Milne and R. Prasad and Y. Ratnasabapathy and A. Santos and M. Wills and T. Agnew and N. Chapman and N. Lewis and B. Mullane",

year = "2001",

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TY - JOUR

T1 - Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6105 individuals with previous stroke or transient ischaemic attack

AU - MacMahon, S.

AU - Neal, B.

AU - Tzourio, C.

AU - Rodgers, A.

AU - Woodward, M.

AU - Cutler, J.

AU - Anderson, C.

AU - Chalmers, J.

AU - Ohkubo, T.

AU - Bouser, M. G.

AU - Davis, S.

AU - Donnan, G.

AU - Hansson, L.

AU - Harrap, S.

AU - Lees, K. R.

AU - Liu, L.

AU - Mancia, G.

AU - Neal, B.

AU - Omae, T.

AU - Reid, J.

AU - Rodgers, A.

AU - Sega, R.

AU - Terent, A.

AU - Tzourio, C.

AU - Warlow, C.

AU - Woodward, M.

AU - Anderson, N.

AU - Bladin, C.

AU - Chambers, B.

AU - Gordon, G.

AU - Sharpe, N.

AU - Collins, R.

AU - Sandercock, P.

AU - Simes, J.

AU - Sleight, P.

AU - Brnabic, A.

AU - Colman, S.

AU - Francis, L.

AU - Lee, A.

AU - Gong, L.

AU - Bousser, M. G.

AU - Yamaguchi, T.

AU - Lees, K. R.

AU - William, F.

AU - Deng, Q.

AU - Hu, D. X.

AU - Wang, W.

AU - Wu, A. L.

AU - Ma, L. Y.

AU - Tao, Z. Y.

AU - Biousse, V.

AU - Berthet, K.

AU - Ben Slamia, L.

AU - Le Denmat, C.

AU - Crespi, S.

AU - Foglia, G.

AU - Fujimoto, C.

AU - Matsumura, S.

AU - Marttala, K.

AU - Pettersson, M.

AU - Safwenberg, M.

AU - Fenton, J.

AU - McIlvenna, Y.

AU - Currie, R.

AU - Bartram, H.

AU - Briad, J.

AU - Clague, A.

AU - Cleverly, Y.

AU - Cosson, M.

AU - Culpan, A.

AU - Douglas, D.

AU - Flett, S.

AU - Gray, B.

AU - Holloway, T.

AU - Milne, A.

AU - Prasad, R.

AU - Ratnasabapathy, Y.

AU - Santos, A.

AU - Wills, M.

AU - Agnew, T.

AU - Chapman, N.

AU - Lewis, N.

AU - Mullane, B.

PY - 2001/9/29

Y1 - 2001/9/29

N2 - Background: Blood pressure is a determinant of the risk of stroke among both hypertensive and non-hypertensive individuals with cerebrovascular disease. However, there is uncertainty about the efficacy and safety of blood-pressure-lowering treatments for many such patients. The perindopril protection against recurrent stroke study (PROGRESS) was designed to determine the effects of a blood-pressure-lowering regimen in hypertensive and non-hypertensive patients with a history of stroke or transient ischaemic attack. Methods: 6105 individuals from 172 centres in Asia, Australasia, and Europe were randomly assigned active treatment (n=3051) or placebo (n=3054). Active treatment comprised a flexible regimen based on the angiotensin-converting-enzyme inhibitor perindopril (4 mg daily), with the addition of the diuretic indapamide at the discretion of treating physicians. The primary outcome was total stroke (fatal or non-fatal). Analysis was by intention to treat. Findings: Over 4 years of follow up, active treatment reduced blood pressure by 9/4 mm Hg. 307 (10%) individuals assigned active treatment suffered a stroke, compared with 420 (14%) assigned placebo (relative risk reduction 28% [95% CI 17-38], p

AB - Background: Blood pressure is a determinant of the risk of stroke among both hypertensive and non-hypertensive individuals with cerebrovascular disease. However, there is uncertainty about the efficacy and safety of blood-pressure-lowering treatments for many such patients. The perindopril protection against recurrent stroke study (PROGRESS) was designed to determine the effects of a blood-pressure-lowering regimen in hypertensive and non-hypertensive patients with a history of stroke or transient ischaemic attack. Methods: 6105 individuals from 172 centres in Asia, Australasia, and Europe were randomly assigned active treatment (n=3051) or placebo (n=3054). Active treatment comprised a flexible regimen based on the angiotensin-converting-enzyme inhibitor perindopril (4 mg daily), with the addition of the diuretic indapamide at the discretion of treating physicians. The primary outcome was total stroke (fatal or non-fatal). Analysis was by intention to treat. Findings: Over 4 years of follow up, active treatment reduced blood pressure by 9/4 mm Hg. 307 (10%) individuals assigned active treatment suffered a stroke, compared with 420 (14%) assigned placebo (relative risk reduction 28% [95% CI 17-38], p

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U2 - 10.1016/S0140-6736(01)06178-5

DO - 10.1016/S0140-6736(01)06178-5

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JO - The Lancet

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SN - 0140-6736

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