Randomized comparative study of hemaccel vs. albumin infusion after total paracentesis in cirrhotic patients with refractory ascites

F. Salerno, S. Badalamenti, E. Lorenzano, P. Moser, P. Incerti

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

Fifty-four cirrhotic patients with refractory ascites were treated with one-session large-volume paracentesis and randomly assigned to two groups. The first group was infused with human albumin, and the second group was infused with hemaccel at doses with comparable oncotic power. The two groups were compared for incidence of complications, recurrence of massive ascites after hospital dismissal and survival rate. The incidence of complications traditionally related to paracentesis, the probability of requiring readmission to the hospital for ascites (p = 0.48) and the probability of survival after entry into the study (p = 0.85) were the same for the two groups. A multivariate analysis of 16 parameters, including treatment modality, identified absolute unresponsiveness to diuretics as the only independent predictor of mortality. These results indicate that hemaccel infusion may safely replace albumin infusion after total paracentesis for cirrhotic patients with refractory ascites.

Original languageEnglish
Pages (from-to)707-713
Number of pages7
JournalHepatology
Volume13
Issue number4
DOIs
Publication statusPublished - 1991

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Paracentesis
Ascites
Albumins
Patient Readmission
Incidence
Diuretics
Multivariate Analysis
Survival Rate
Recurrence
Survival
Mortality
Hemaccel

ASJC Scopus subject areas

  • Hepatology

Cite this

Randomized comparative study of hemaccel vs. albumin infusion after total paracentesis in cirrhotic patients with refractory ascites. / Salerno, F.; Badalamenti, S.; Lorenzano, E.; Moser, P.; Incerti, P.

In: Hepatology, Vol. 13, No. 4, 1991, p. 707-713.

Research output: Contribution to journalArticle

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