Randomized comparison of two chemotherapy, radiotherapy schemes for stage III and IV unresectable squamous cell carcinoma of the head and neck

Marco Merlano, Riccardo Rosso, Mario Roberto Sertoli, Marco Benasso, Almalina Bacigalupo, Andrea Ardizzoni, Paola Mereu, Giovanni Margarino, Marco Scala, Vito Vitale, Renzo Corvö, Andrea Grimaldi, Eugenio Pallestrini, Marco Barbieri, Emilio Accomando, Felice Scasso, Vittorio Novella, Maurizio Sampietro, Paolo Fracchia, Fulvio BremaMaurizio Moratti, Leonardo Santi

Research output: Contribution to journalArticlepeer-review

Abstract

Between August 1983 and December 1986,116 previously untreated patients with squamous cell carcinoma of the head and neck were randomized to receive induction chemotherapy followed by radiotherapy given in conventional fractions (55 patients, arm A) or an alternating chemotherapy and radiotherapy (3 courses of 20 Gy, 10 daily fractions each; 61 patients, arm B). The same chemotherapy was used in both arms: 6 mg/m2 vinblastine sulfate, hour 0; 30 mg bleomycin, hour 6; 200 mg methotrexate, hours 24 to 26; 45 mg leucovorin, hour 48. Forty-five patients had stage III disease and 71 had stage IV disease. All patients were evaluated for survival, 112 for toxicity, and 105 for analyses of response and time from the start of treatment until progression of disease. At the end of the combined treatment, we observed an overall response rate of 52% in arm A and an overall response rate of 64.9% in arm B. The incidence of mucositis was more relevant in arm B compared to arm A (P

Original languageEnglish
Pages (from-to)531-535
Number of pages5
JournalLaryngoscope
Volume100
Issue number5
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Otorhinolaryngology

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