Randomized controlled trial on the efficacy of a multilevel non-pharmacologic intervention in older adults with subjective memory decline: design and baseline findings of the E.Mu.N.I. study

Elena Rolandi, Alessandra Dodich, Samantha Galluzzi, Clarissa Ferrari, Sara Mandelli, Federica Ribaldi, Giulio Munaretto, Claudia Ambrosi, Roberto Gasparotti, Davide Violi, Nicola Canessa, Sandro Iannaccone, Alessandra Marcone, Andrea Falini, Harald Hampel, Giovanni B Frisoni, Chiara Cerami, Enrica Cavedo

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Alzheimer's Disease (AD) is a multifactorial disorder driven by genetic and modifiable lifestyle risk factors. Lifestyle primary prevention initiatives may reduce the prevalence and incidence of dementia in older adults.

OBJECTIVES: The E.Mu.N.I study is a randomized controlled trial investigating the effect of multilevel non-pharmacologic interventions on cognitive performances (primary outcome) and structural and vascular brain MRI markers (secondary outcome), as well as markers of brain functional connectivity change (exploratory outcome), in older adults with subjective memory decline (SMD). Here, we present the study design and the baseline features of the sample.

METHODS: Cognitively intact older adults with SMD, enrolled between February 2016 and June 2017, were randomly assigned to one of the 3 interventions for 1 year: Active Control Intervention (ACI), i.e., educational lessons; Partial Intervention (PI), i.e., homotaurine administration (100 mg/die) and lessons on the Mediterranean diet; Multilevel Intervention (MI), i.e., PI plus computerized cognitive training and physical exercise training.

RESULTS: One-hundred and twenty-eight eligible participants were enrolled (66% female; age: 68 ± 5 years). Eighty-two percent of the sample was composed of volunteers with SMD from the community. Participants were randomly allocated to the interventions as follows: ACI (N = 40), PI (N = 44), MI (N = 44). No significant differences among groups emerged on socio-demographic, clinical-neuropsychological variables and MRI markers at baseline.

CONCLUSIONS: The outcomes obtained from the E.Mu.N.I. study will clarify the efficacy of multilevel non-pharmacologic interventions on cognitive and neuroimaging markers in SMD individuals. This is a crucial step forward for the development of cost-effective non-pharmacologic primary prevention initiatives for AD.

Original languageEnglish
Pages (from-to)817-826
Number of pages10
JournalAging Clin. Exp. Res.
Volume32
Issue number5
DOIs
Publication statusPublished - May 2020

Keywords

  • Aged
  • Brain/physiopathology
  • Dementia/physiopathology
  • Exercise
  • Female
  • Humans
  • Life Style
  • Magnetic Resonance Imaging
  • Male
  • Memory
  • Memory Disorders/physiopathology
  • Middle Aged

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