Randomized, double-blind, placebo-controlled trial to evaluate the effect of Helicobacter pylori eradication on glucose homeostasis in type 2 diabetic patients

Anna Rita Bonfigli, M. Boemi, Roberto Festa, P. Bonazzi, G. Brandoni, Liana Spazzafumo, Fabiola Olivieri, Antonio Ceriello, Stefano Genovese, Roberto Testa

Research output: Contribution to journalArticle

Abstract

Background and aims Literature data suggest an association between Helicobacter pylori infection and glucose homeostasis. However, a causative link between them has not been demonstrated yet. The aim of this study is to investigate the effect of H. pylori eradication on glucose homeostasis in patients with type 2 diabetes. Methods and results A randomized, double-blind, placebo-controlled trial was conducted to investigate the effect of H. pylori eradication on glucose homeostasis in 154 patients with type 2 diabetes and who tested positive for H. pylori infection (mean age (SD), 63.1 (8.1) years). Subjects were assigned to H. pylori eradication treatment or placebo. Metabolic and inflammatory parameters were measured in all subjects at baseline and 4 weeks after the treatment. H. pylori eradication led to an improvement in glucose homeostasis, measured by HOMA-IR (p < 0.001) and KITT (0 = 0.041), due to the decrease in fasting insulin levels (p = 0.004). The results also showed that lower levels of inflammatory parameters were present after eradication. Conclusion To our knowledge this is the first randomized, double blind, controlled study where the effect of H. pylori eradication on glucose homeostasis in subjects with type 2 diabetes has been investigated. Our findings demonstrate that H. pylori eradication improves glucose homeostasis in patients with type 2 diabetes through a decrease in pro-inflammatory factors. Trial registration number: ACTRN12609000255280 (https://www.anzctr.org.au/).

Original languageEnglish
Pages (from-to)893-898
Number of pages6
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume26
Issue number10
DOIs
Publication statusPublished - Oct 1 2016

Keywords

  • Diabetes mellitus type 2
  • Helicobacter pylori
  • Inflammation
  • Insulin resistance
  • Randomized clinical trial

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Randomized, double-blind, placebo-controlled trial to evaluate the effect of Helicobacter pylori eradication on glucose homeostasis in type 2 diabetic patients'. Together they form a unique fingerprint.

  • Cite this