Randomized, double-blinded, vehicle-controlled, split-face study to evaluate the effects of topical application of a Gold Silk Sericin/Niacinamide/Signaline complex on biophysical parameters related to skin ageing

E. Berardesca, M. Ardigo, N. Cameli, M. Mariano, M. Agozzino, P. J. Matts

Research output: Contribution to journalArticle

Abstract

Synopsis Objective To investigate the effects of topical application of a Gold Silk Sericin (GSS) complex on biophysical parameters related to skin ageing. Methods A range of non-invasive bioengineering methods were deployed in an 8-week randomized, double-blinded, vehicle-controlled, split-face study among 40 female subjects aged 40-70. Endpoints measured included expert grades of skin condition, stratum corneum (SC) hydration, SC barrier function, elasticity and surface topography. Results The GSS complex produced significant single-variable (P <0.05) improvements in SC hydration, barrier function, elasticity and surface topography compared with the Vehicle control. Conclusion The GSS complex examined in this study represents an interesting new cosmetic topical technology with which to address multiple aspects of aged/photoaged female facial skin.

Original languageEnglish
Pages (from-to)606-612
Number of pages7
JournalInternational Journal of Cosmetic Science
Volume37
Issue number6
DOIs
Publication statusPublished - Dec 1 2015

Fingerprint

Sericins
Skin Aging
Silk
Niacinamide
Gold
Cornea
Skin
Aging of materials
Elasticity
Surface topography
Hydration
Bioengineering
Cosmetics
Technology

Keywords

  • hair + body care
  • moisturisation
  • skin repair/acne/rosacea/dandruff/striae

ASJC Scopus subject areas

  • Dermatology
  • Colloid and Surface Chemistry
  • Ageing
  • Drug Discovery
  • Pharmaceutical Science
  • Chemistry (miscellaneous)

Cite this

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title = "Randomized, double-blinded, vehicle-controlled, split-face study to evaluate the effects of topical application of a Gold Silk Sericin/Niacinamide/Signaline complex on biophysical parameters related to skin ageing",
abstract = "Synopsis Objective To investigate the effects of topical application of a Gold Silk Sericin (GSS) complex on biophysical parameters related to skin ageing. Methods A range of non-invasive bioengineering methods were deployed in an 8-week randomized, double-blinded, vehicle-controlled, split-face study among 40 female subjects aged 40-70. Endpoints measured included expert grades of skin condition, stratum corneum (SC) hydration, SC barrier function, elasticity and surface topography. Results The GSS complex produced significant single-variable (P <0.05) improvements in SC hydration, barrier function, elasticity and surface topography compared with the Vehicle control. Conclusion The GSS complex examined in this study represents an interesting new cosmetic topical technology with which to address multiple aspects of aged/photoaged female facial skin.",
keywords = "hair + body care, moisturisation, skin repair/acne/rosacea/dandruff/striae",
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T1 - Randomized, double-blinded, vehicle-controlled, split-face study to evaluate the effects of topical application of a Gold Silk Sericin/Niacinamide/Signaline complex on biophysical parameters related to skin ageing

AU - Berardesca, E.

AU - Ardigo, M.

AU - Cameli, N.

AU - Mariano, M.

AU - Agozzino, M.

AU - Matts, P. J.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Synopsis Objective To investigate the effects of topical application of a Gold Silk Sericin (GSS) complex on biophysical parameters related to skin ageing. Methods A range of non-invasive bioengineering methods were deployed in an 8-week randomized, double-blinded, vehicle-controlled, split-face study among 40 female subjects aged 40-70. Endpoints measured included expert grades of skin condition, stratum corneum (SC) hydration, SC barrier function, elasticity and surface topography. Results The GSS complex produced significant single-variable (P <0.05) improvements in SC hydration, barrier function, elasticity and surface topography compared with the Vehicle control. Conclusion The GSS complex examined in this study represents an interesting new cosmetic topical technology with which to address multiple aspects of aged/photoaged female facial skin.

AB - Synopsis Objective To investigate the effects of topical application of a Gold Silk Sericin (GSS) complex on biophysical parameters related to skin ageing. Methods A range of non-invasive bioengineering methods were deployed in an 8-week randomized, double-blinded, vehicle-controlled, split-face study among 40 female subjects aged 40-70. Endpoints measured included expert grades of skin condition, stratum corneum (SC) hydration, SC barrier function, elasticity and surface topography. Results The GSS complex produced significant single-variable (P <0.05) improvements in SC hydration, barrier function, elasticity and surface topography compared with the Vehicle control. Conclusion The GSS complex examined in this study represents an interesting new cosmetic topical technology with which to address multiple aspects of aged/photoaged female facial skin.

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