Randomized evaluation of intracoronary nitroprusside vs. adenosine after thrombus aspiration during primary percutaneous coronary intervention for the prevention of no-reflow in acute myocardial infarction: The REOPEN-AMI study protocol

Giampaolo Niccoli, Domenico D'amario, Cristina Spaziani, Nicola Cosentino, Marcello Marino, Stefano Rigattieri, Paolo L. Schiavo, Maria Rosaria De Vita, Fabio Tarantino, Antonio Bartorelli, Franco Fabbiocchi, Francesco Prati, Fabrizio Imola, Marco Valgimigli, Roberto Ferrari, Filippo Crea

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Thrombus aspiration improves microvascular obstruction in patients with acute myocardial infarction treated by percutaneous coronary intervention. However, drugs such as nitroprusside and adenosine have not yet been tested as adjuncts to thrombus aspiration. Therefore, we designed a placebo-controlled, randomized, open-label, blind-examination, multicenter trial assessing the effects of intracoronary nitroprusside or adenosine on microvascular obstruction in patients undergoing primary or rescue percutaneous coronary intervention and thrombus aspiration. METHODS AND RESULTS: Six hospitals in Italy participate in the REOPEN-AMI study. Two hundred and forty consecutive patients with acute myocardial infarction undergoing primary or rescue percutaneous coronary intervention and thrombus aspiration are randomly allocated 1: 1: 1 to receive either intracoronary nitroprusside, adenosine or placebo. The primary end-point is the incidence of ST resolution greater than 70% on surface ECG at 90 min after the procedure. Secondary end-points are: incidence of angiographic no-reflow (thrombolysis in myocardial infarction flow ≤2 or 3 with a myocardial blush grade

Original languageEnglish
Pages (from-to)585-592
Number of pages8
JournalJournal of Cardiovascular Medicine
Volume10
Issue number7
DOIs
Publication statusPublished - Jul 2009

Keywords

  • Acute myocardial infarction
  • Intracoronary adenosine
  • Intracoronary nitroprusside
  • Randomized clinical trial

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint

Dive into the research topics of 'Randomized evaluation of intracoronary nitroprusside vs. adenosine after thrombus aspiration during primary percutaneous coronary intervention for the prevention of no-reflow in acute myocardial infarction: The REOPEN-AMI study protocol'. Together they form a unique fingerprint.

Cite this