Randomized study of sertraline and low-dose amitriptyline in patients with Parkinson's disease and depression: Effect on quality of life

Angelo Antonini, Silvana Tesei, Anna Zecchinelli, Paolo Barone, Danilo De Gaspari, Margherita Canesi, Giorgio Sacilotto, Nicotta Meucci, Claudio Mariani, Gianni Pezzoli

Research output: Contribution to journalArticle

Abstract

We assessed the effect of 3-month treatment of sertraline (50 mg) or low-dose amitriptyline (25 mg) on depression and quality of life in 31 patients with Parkinson's disease in a prospective single-blind randomized study. Both drugs significantly reduced the Hamilton Depression Rating Scale (HDRS-17) score. Completion rate was 75% for sertra-line (12 of 16) and 73% for amitriptyline (11 of 15). Responder rate (HDRS-17 score reduction ≥ 50%) was 83.3% for sertra-line and 72.7% for amitriptyline. Sertraline but not amitripty-line treatment determined a significant benefit on quality of life (PDQ-39 scale). We found no change in Unified Parkinson's Disease Rating Scale scores. However, the improvement in specific PDQ-39 subscores (mobility, activities of daily living, and stigma) suggests that depression affects patient self-perception of motor function and further emphasizes the need for its treament.

Original languageEnglish
Pages (from-to)1119-1122
Number of pages4
JournalMovement Disorders
Volume21
Issue number8
DOIs
Publication statusPublished - Aug 2006

Keywords

  • Amitriptyline
  • Depression
  • Parkinson's disease
  • Sertraline

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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    Antonini, A., Tesei, S., Zecchinelli, A., Barone, P., De Gaspari, D., Canesi, M., Sacilotto, G., Meucci, N., Mariani, C., & Pezzoli, G. (2006). Randomized study of sertraline and low-dose amitriptyline in patients with Parkinson's disease and depression: Effect on quality of life. Movement Disorders, 21(8), 1119-1122. https://doi.org/10.1002/mds.20895