Randomized study with cyclosporine in kidney transplantation: 10-year follow-up

Claudio Ponticelli, Giovanni Civati, Antonio Tarantino, Filippo Quarto Di Palo, Giuseppe Corbetta, Luigi Minetti, Antonio Vegeto, Lino Belli

Research output: Contribution to journalArticlepeer-review

Abstract

This study presents the 10-yr follow-up results of a multicenter controlled trial on 108 recipients of cadaveric renal transplantation, randomized to receive cyclosporine (N = 55) or azathioprine (N = 53), both in combination with steroids. The 10-yr patient survival rate was 89% in the cyclosporine group and 83% in the azathioprine group (P = not significant (NS)); the 10-yr graft survival was 56% and 35%, respectively (log-rank test, P = 0.009). The half-life of grafts functioning after 1 yr was 15.4 ± 3.9 versus 10.6 ± 3.6, P = NS). The rate of early rejection in the cyclosporine group was significantly lower than that in the azathioprine group (0.30 versus 1.4, P <0.01). Although the mean creatinine clearance rate was always higher in the azathioprine group, the decline in graft function from the first to the tenth yr was not significantly different between the two groups (- 13.0 ± 16.4 versus -12.3 ± 19 mL/min, P = Ns). In cadaveric renal transplantation, cyclosporine allows better graft survival than azathioprine, not only in the short term but also in the long term, with similar attrition of graft function for up to 10 yr.

Original languageEnglish
Pages (from-to)792-797
Number of pages6
JournalJournal of the American Society of Nephrology
Volume7
Issue number5
Publication statusPublished - May 1996

Keywords

  • Graft half-life
  • Long term
  • Prospective study

ASJC Scopus subject areas

  • Nephrology

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