Randomized trial of endobronchial ultrasound-guided transbronchial needle aspiration with and without rapid on-site evaluation for lung cancer genotyping

Rocco Trisolini, Alessandra Cancellieri, Carmine Tinelli, Dario De Biase, Ilaria Valentini, Gianpiero Casadei, Daniela Paioli, Franco Ferrari, Giovanni Gordini, Marco Patelli, Giovanni Tallini

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Experts and scientifi c society guidelines recommend that rapid on-site evaluation (ROSE) be used with endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) to optimize lung cancer genotyping, but no comparative trial has been carried out to confi rm and quantify its usefulness. METHODS: To assess the influence of ROSE on the yield of EBUS-TBNA for a multigene molecular analysis of lung cancer samples, consecutive patients with suspected or known advanced lung cancer were randomized to undergo EBUS-TBNA without ROSE (EBUS arm) or with ROSE (ROSE arm). Th e primary end point was the rate of the successful accomplishment of the institution's clinical protocol for molecular profi ling of nonsquamous non-small cell lung cancer (EGFR and KRAS testing, followed by ALK testing for tumors with EGFR and KRAS wild-type status). RESULTS: Complete genotyping was achieved in 108 of 126 patients (85.7%) (90.8% in the ROSE arm vs 80.3% in the EBUS arm, P

Original languageEnglish
Pages (from-to)1430-1437
Number of pages8
JournalChest
Volume148
Issue number6
DOIs
Publication statusPublished - Dec 1 2015

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

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