Randomized Trial of Near-infrared Incisionless Fluorescent Cholangiography

Fernando Dip, Emanuelle LoMenzo, Luis Sarotto, Edward Phillips, Hernan Todeschini, Mario Nahmod, Lisandro Alle, Sylke Schneider, Ludwig Kaja, Luigi Boni, Pedro Ferraina, Thomas Carus, Norihiro Kokudo, Takeaki Ishizawa, Mathew Walsh, Conrad Simpfendorfer, Roy Mayank, Kevin White, Raul J Rosenthal

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Incisionless near-infrared fluorescent cholangiography (NIFC) is emerging as a promising tool to enhance the visualization of extrahepatic biliary structures during laparoscopic cholecystectomies.

METHODS: We conducted a single-blind, randomized, 2-arm trial comparing the efficacy of NIFC (n = 321) versus white light (WL) alone (n = 318) during laparoscopic cholecystectomy. Using the KARL STORZ Image1 S imaging system with OPAL1 technology for NIR/ICG imaging, we evaluated the detection rate for 7 biliary structures-cystic duct (CD), right hepatic duct (RHD), common hepatic duct, common bile duct, cystic common bile duct junction, cystic gallbladder junction (CGJ), and accessory ducts -before and after surgical dissection. Secondary calculations included multivariable analysis for predictors of structure visualization and comparing intergroup biliary duct injury rates.

RESULTS: Predissection detection rates were significantly superior in the NIFC group for all 7 biliary structures, ranging from 9.1% versus 2.9% to 66.6% versus 36.6% for the RHD and CD, respectively, with odds ratios ranging from 2.3 (95% CI 1.6-3.2) for the CGJ to 3.6 (1.6-9.3) for the RHD. After dissection, similar intergroup differences were observed for all structures except CD and CGJ, for which no differences were observed. Significant odds ratios ranged from 2.4 (1.7-3.5) for the common hepatic duct to 3.3 (1.3-10.4) for accessory ducts. Increased body mass index was associated with reduced detection of most structures in both groups, especially before dissection. Only 2 patients, both in the WL group, sustained a biliary duct injury.

CONCLUSIONS: In a randomized controlled trial, NIFC was statistically superior to WL alone visualizing extrahepatic biliary structures during laparoscopic cholecystectomy.

REGISTRATION NUMBER: NCT02702843.

Original languageEnglish
Pages (from-to)992-999
Number of pages8
JournalAnnals of Surgery
Volume270
Issue number6
DOIs
Publication statusPublished - Dec 2019

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Dip, F., LoMenzo, E., Sarotto, L., Phillips, E., Todeschini, H., Nahmod, M., Alle, L., Schneider, S., Kaja, L., Boni, L., Ferraina, P., Carus, T., Kokudo, N., Ishizawa, T., Walsh, M., Simpfendorfer, C., Mayank, R., White, K., & Rosenthal, R. J. (2019). Randomized Trial of Near-infrared Incisionless Fluorescent Cholangiography. Annals of Surgery, 270(6), 992-999. https://doi.org/10.1097/SLA.0000000000003178