Randomized trial on the effect of sevoflurane on polypropylene membrane oxygenator performance

Caetano Nigro Neto, Renato Arnoni, Bilal Smaili Rida, Giovanni Landoni, Maria Angela Tardelli

Research output: Contribution to journalArticle


Objectives: Volatile anesthetics have cardioprotective properties that improve clinically relevant outcomes in cardiac surgery, and can be used during cardiopulmonary bypass (CPB) through adapted calibrated vaporizers together with air and oxygen (O2). The effect of volatile agents on the membrane oxygenator is unknown. The aim of this study was to evaluate, for the first time, the performance of semiporous polypropylene membrane oxygenators after the use of sevoflurane vaporized during CPB in cardiac surgery. Design: A prospective, randomized, controlled trial. Setting: Teaching hospital. Participants: Thirty-two consecutive patients scheduled to undergo coronary artery bypass graft with CPB. Interventions: Patients were allocated randomly to receive either a volatile anesthetic (sevoflurane 1%-3%, 16 patients) or an intravenous hypnotic (midazolam, 16 patients) during CPB. After surgery, the membrane oxygenators used during CPB were tested with regard to O2 transfer, carbon dioxide transfer, and pressure drop. Measurements and Main Results: The authors observed no protocol deviation or crossover. The performance of the membrane oxygenator was similar between the 2 groups, as documented by O2 transfer (55±6.4 mL/min/L in the sevoflurane group versus 57±4.7 mL/min/L in the midazolam group, p = 0.4), carbon dioxide transfer, and pressure drop. Conclusions: The use of sevoflurane during CPB in cardiac surgery does not affect membrane oxygenator performance.

Original languageEnglish
Pages (from-to)903-907
Number of pages5
JournalJournal of Cardiothoracic and Vascular Anesthesia
Issue number5
Publication statusPublished - Oct 2013


  • anesthesia
  • cardiopulmonary bypass
  • drugs
  • evaluation
  • gas transfer
  • membrane oxygenator
  • oxygen
  • sevoflurane

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Anesthesiology and Pain Medicine

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