Human blood lymphocytes express membrane receptors for histamine. In vivo and in vitro studies showed that cimetidine, and H2-receptor antagonist, exerts some modifications on lymphocyte reactivity as: increase migration inhibitory factor (MIF) production, enhancement in E-rosette number and in blastogenic response to mitogens. The purpose of the present work was to verify if Ranitidine, a new H2-receptor antagonist, woul be able to modify the reactivity of normal lymphocytes to mitogens in vitro. In a first series of experiments lymphocytes were preincubated for 30 min. with Ranitidine 4000 μg/ml over the entire culture period. The data demonstrate that Ranitidine does not modify either the spontaneous lymphocyte transformation or the mitogenic lymphocyte in vitro response to mitogens. Such an effect was observed when cells were treated with high doses of Ranitidine for a brief period of time as well as when cells were treated with lower doses of Ranitidine for a longer period of time.
|Number of pages||1|
|Journal||IRCS Medical Science|
|Publication status||Published - 1982|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)