Rantes distribution and cellular localization in the brain of HIV-infected patients

L. Vago, M. Nebuloni, S. Bonetto, A. Pellegrinelli, P. Zerbi, A. Ferri, E. Lavril, M. Capra, M. P. Grassi, G. Costanzi

Research output: Contribution to journalArticle

Abstract

Objective: To study the immunochemical distribution of Rantes chemokine and its correlation with HIV-p24 expression, in brains with HIV-related lesions. Material and methods: 17 HIV-positive cases of HIV-related brain lesions, 7 HIV-positive cases without cerebral HIV-related lesions (5 with opportunistic brain diseases), and 7 HIV-negative cases as controls (4 with brain lesion) were selected. Results: High expression of Rantes was observed in the cases with inflammatory brain lesions (22/24 HIV-positive and 2/7 HIV-negative patients). Positivity was observed in the diffuse and nodular microglial cells and lymphocytes. In the patients with HIV-related lesions, the presence of Rantes-stained microglia did not correlate with that of HIV-p24-positive cells. Positive astrocytes were only found in the HIV-positive patients. Multinucleated giant cells were always Rantes-negative. Conclusions: Our results seem to demonstrate the role of Rantes chemokine in inducing inflammatory brain perivascular and microglial reactions both in HIV-positive and -negative patients.

Original languageEnglish
Pages (from-to)139-145
Number of pages7
JournalClinical Neuropathology
Volume20
Issue number4
Publication statusPublished - 2001

Keywords

  • Central nervous system
  • Chemokines
  • HIV
  • Rantes

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Neuroscience(all)

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    Vago, L., Nebuloni, M., Bonetto, S., Pellegrinelli, A., Zerbi, P., Ferri, A., Lavril, E., Capra, M., Grassi, M. P., & Costanzi, G. (2001). Rantes distribution and cellular localization in the brain of HIV-infected patients. Clinical Neuropathology, 20(4), 139-145.