Rapamycin in islet transplantation: Friend or foe?

Thierry Berney, Antonio Secchi

Research output: Contribution to journalArticle

Abstract

The Edmonton protocol was undoubtedly a major step forward in the history of islet transplantation. Its immunosuppression regimen was largely based on the mTOR inhibitor rapamycin (sirolimus), which remains the most frequently used immunosuppressive drug in clinical islet transplant protocols. As time reveals the somewhat disappointing long-term results achieved with the Edmonton protocol, a number of publications have appeared addressing the potential beneficial or deleterious role of rapamycin on islet cell engraftment, function survival and regeneration, as well as on its side-effects in human subjects. This paper reviews the sometimes contradictory evidence on the impact of rapamycin in islet transplantation.

Original languageEnglish
Pages (from-to)153-161
Number of pages9
JournalTransplant International
Volume22
Issue number2
DOIs
Publication statusPublished - Feb 2009

Keywords

  • Islet function
  • Islet transplantation
  • Rapamycin
  • Sirolimus
  • Toxicity

ASJC Scopus subject areas

  • Transplantation

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