Rapid and low-cost tools derived from plants to face emerging/re-emerging infectious diseases and bioterrorism agents

Rosella Franconi, Elena Illiano, Francesca Paolini, Silvia Massa, Aldo Venuti, Olivia Costantina Demurtas

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Whether naturally occurring or man-made, biological threats pose a severe risk in an increasingly globalized world. The dual-use nature of biological research, with its most recent advances in biotechnology (‘synthetic biology’, gene editing, nanotechnologies etc.) and the rapid diffusion of knowledge, raise proliferation concerns of biological weapons by non-state actors. Thus, there is an urgent need to develop measures intended to enhance diagnostic, prophylactic and therapeutic capabilities and capacities to improve the ability of society to combat infectious diseases outbreaks, as well as to alleviate the effects of bioterrorism attacks. We present here two examples of biotechnology usage for biodefence purposes: (i) plants as biofactories for the rapid production of improved biopharmaceuticals (‘Plant Molecular Farming’), and (ii) plant sequences as immune-modulating agents to enhance the efficacy of genetic vaccines. These platforms represent two promising (and complementary) approaches for the rapid and low-cost production of countermeasures (diagnostics and vaccine candidates) against emerging, re-emerging and bioterrorism-related infections.

Original languageEnglish
Title of host publicationNATO Science for Peace and Security Series A
Subtitle of host publicationChemistry and Biology
PublisherSpringer Verlag
Pages123-139
Number of pages17
DOIs
Publication statusPublished - Jan 1 2018

Publication series

NameNATO Science for Peace and Security Series A: Chemistry and Biology
ISSN (Print)1874-6489

Keywords

  • Biothreat
  • Bioweapon
  • Diagnostics
  • Genetic vaccines
  • Infectious disease
  • Molecular farming
  • Plant sequences
  • SARS-CoV

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Safety, Risk, Reliability and Quality

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  • Cite this

    Franconi, R., Illiano, E., Paolini, F., Massa, S., Venuti, A., & Demurtas, O. C. (2018). Rapid and low-cost tools derived from plants to face emerging/re-emerging infectious diseases and bioterrorism agents. In NATO Science for Peace and Security Series A: Chemistry and Biology (pp. 123-139). (NATO Science for Peace and Security Series A: Chemistry and Biology). Springer Verlag. https://doi.org/10.1007/978-94-024-1263-5_10