Rapid and simple GLC determination of valproic acid and ethosuximide in plasma of epileptic patients

R. Riva, F. Albani, A. Baruzzi

Research output: Contribution to journalArticle

Abstract

A GLC method for the determination of valproic acid and ethosuximide in plasma was developed. The procedure involved a single solvent extraction of drugs from acidified plasma samples, followed by a GLC injection of the unconcentrated organic phase. This rapid, sensitive, specific, and reproducible method has been used for 2 years for the routine determination of plasma levels of valproic acid and ethosuximide in epileptic patients who receive other antiepileptic drugs simultaneously.

Original languageEnglish
Pages (from-to)110-111
Number of pages2
JournalJournal of Pharmaceutical Sciences
Volume71
Issue number1
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Molecular Medicine
  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science
  • Pharmacology

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