Rapid and Sustained Efficacy of Golimumab in the Treatment of Multirefractory Uveitis Associated with Behçet’s Disease

Claudia Fabiani, Jurgen Sota, Donato Rigante, Antonio Vitale, Giacomo Emmi, Lorenzo Vannozzi, Rossella Franceschini, Daniela Bacherini, Bruno Frediani, Mauro Galeazzi, Gian Marco Tosi, Luca Cantarini

Research output: Contribution to journalArticle

Abstract

Purpose: To evaluate golimumab (GOL) efficacy in the management of Behçet’s disease (BD)-related uveitis. Methods: We retrospectively collected data from 5 patients (8 eyes) with at least two recent relapses of uveitis, treated with GOL at the standard dose of 50 mg every 4 weeks. Results: A complete control of intraocular inflammation was observed in 7/8 eyes (87.5%) at 12-month follow-up. The number of relapses 12 months before and after GOL initiation was 11 and 1, respectively. At baseline, four eyes had active retinal vasculitis (RV). At 3-month follow-up evaluation RV resolved in all eyes. Mean Best Corrected Visual Acuity was 6.93 ± 4.34 at baseline and 7.32 ± 3.87 at 12-months follow-up. Conclusion: We confirm GOL efficacy in reducing intraocular inflammation in BD, both in term of reduction in the number of uveitis relapses and in achieving a prompt resolution of active RV.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalOcular Immunology and Inflammation
DOIs
Publication statusAccepted/In press - Oct 7 2017

Keywords

  • Behçet’s disease
  • golimumab
  • intraocular inflammation
  • retinal vasculitis
  • uveitis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Ophthalmology

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    Fabiani, C., Sota, J., Rigante, D., Vitale, A., Emmi, G., Vannozzi, L., Franceschini, R., Bacherini, D., Frediani, B., Galeazzi, M., Tosi, G. M., & Cantarini, L. (Accepted/In press). Rapid and Sustained Efficacy of Golimumab in the Treatment of Multirefractory Uveitis Associated with Behçet’s Disease. Ocular Immunology and Inflammation, 1-6. https://doi.org/10.1080/09273948.2017.1351573