Abstract
Acute generalized exanthematous pustulosis (AGEP) is a rare disorder, usually drug-induced, and is clinically characterized by widespread, non-follicular aseptic pustules. Although spontaneous resolution usually occurs once the causative drug has been withdrawn, more severe cases often require treatment with systemic corticosteroids. We report a 63-year-old woman who developed AGEP after a 30-day course of hydroxychloroquine. Extensive re-exacerbation of AGEP after an 18-day course of methylprednisolone led us to switch the treatment to oral ciclosporin with a prompt and satisfactory improvement. Ciclosporin has many inhibitory effects on the main cell population (T cells) involved in AGEP. In particular, a significant reduction in producton of interleukin-8 by T cells is a possible explanation of the rapid remission observed in this case. To our knowledge, this is the first reported case of AGEP successfully treated with ciclosporin.
| Original language | English |
|---|---|
| Journal | Clinical and Experimental Dermatology |
| Volume | 34 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Dec 2009 |
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ASJC Scopus subject areas
- Dermatology
Cite this
Rapid clearing of acute generalized exanthematous pustulosis after administration of ciclosporin. / Di Lernia, V.; Grenzi, L.; Guareschi, E.; Ricci, C.
In: Clinical and Experimental Dermatology, Vol. 34, No. 8, 12.2009.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Rapid clearing of acute generalized exanthematous pustulosis after administration of ciclosporin
AU - Di Lernia, V.
AU - Grenzi, L.
AU - Guareschi, E.
AU - Ricci, C.
PY - 2009/12
Y1 - 2009/12
N2 - Acute generalized exanthematous pustulosis (AGEP) is a rare disorder, usually drug-induced, and is clinically characterized by widespread, non-follicular aseptic pustules. Although spontaneous resolution usually occurs once the causative drug has been withdrawn, more severe cases often require treatment with systemic corticosteroids. We report a 63-year-old woman who developed AGEP after a 30-day course of hydroxychloroquine. Extensive re-exacerbation of AGEP after an 18-day course of methylprednisolone led us to switch the treatment to oral ciclosporin with a prompt and satisfactory improvement. Ciclosporin has many inhibitory effects on the main cell population (T cells) involved in AGEP. In particular, a significant reduction in producton of interleukin-8 by T cells is a possible explanation of the rapid remission observed in this case. To our knowledge, this is the first reported case of AGEP successfully treated with ciclosporin.
AB - Acute generalized exanthematous pustulosis (AGEP) is a rare disorder, usually drug-induced, and is clinically characterized by widespread, non-follicular aseptic pustules. Although spontaneous resolution usually occurs once the causative drug has been withdrawn, more severe cases often require treatment with systemic corticosteroids. We report a 63-year-old woman who developed AGEP after a 30-day course of hydroxychloroquine. Extensive re-exacerbation of AGEP after an 18-day course of methylprednisolone led us to switch the treatment to oral ciclosporin with a prompt and satisfactory improvement. Ciclosporin has many inhibitory effects on the main cell population (T cells) involved in AGEP. In particular, a significant reduction in producton of interleukin-8 by T cells is a possible explanation of the rapid remission observed in this case. To our knowledge, this is the first reported case of AGEP successfully treated with ciclosporin.
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UR - http://www.scopus.com/inward/citedby.url?scp=72549094293&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2230.2009.03480.x
DO - 10.1111/j.1365-2230.2009.03480.x
M3 - Article
C2 - 19663832
AN - SCOPUS:72549094293
VL - 34
JO - Clinical and Experimental Dermatology
JF - Clinical and Experimental Dermatology
SN - 0307-6938
IS - 8
ER -