Rapid detection of illicit drugs in neat saliva using desorption/ionization on porous silicon

Taryn Guinan, Maurizio Ronci, Hilton Kobus, Nicolas H. Voelcker

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The ability to detect illicit drugs directly in oral fluids is of major interest for roadside, workplace and athlete drug testing. For example, roadside testing for popular drugs of abuse is being rolled out by law enforcement agencies following the introduction of legislation in several countries all over the world. This paper reports on the direct analysis of methamphetamine, cocaine and 3,4-methylenedioxymethamphetamine in oral fluids using a hydrophobic porous silicon array as a combined drug extraction and concentration medium. Analysis by laser desorption/ionization time-of-flight mass spectrometry (MS) identified these drugs with a sensitivity in line with the suggested confirmatory cut-off concentrations, and 300 times faster. In addition, MS imaging demonstrated good spot-to-spot reproducibility of the signal. Our analytical approach is compatible with multiplexing and is therefore suitable for high-throughput analysis of samples obtained from drug testing in the field. Furthermore, the application of this analytical technology is not limited to illicit drugs or oral fluids. Indeed, we believe that this platform technology could be applied to the high-throughput analysis of diverse metabolites in body fluids.

Original languageEnglish
Pages (from-to)791-798
Number of pages8
JournalTalanta
Volume99
DOIs
Publication statusPublished - Sep 15 2012

Fingerprint

Substance Abuse Detection
Porous silicon
Street Drugs
Silicon
Saliva
Ionization
Desorption
Roadsides
Pharmaceutical Preparations
Mass spectrometry
Fluids
Mass Spectrometry
Testing
Throughput
Technology
N-Methyl-3,4-methylenedioxyamphetamine
Law Enforcement
Methamphetamine
Body fluids
Body Fluids

Keywords

  • DIOS
  • Illicit drug analysis
  • MS imaging
  • Porous silicon

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Rapid detection of illicit drugs in neat saliva using desorption/ionization on porous silicon. / Guinan, Taryn; Ronci, Maurizio; Kobus, Hilton; Voelcker, Nicolas H.

In: Talanta, Vol. 99, 15.09.2012, p. 791-798.

Research output: Contribution to journalArticle

Guinan, Taryn ; Ronci, Maurizio ; Kobus, Hilton ; Voelcker, Nicolas H. / Rapid detection of illicit drugs in neat saliva using desorption/ionization on porous silicon. In: Talanta. 2012 ; Vol. 99. pp. 791-798.
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