Rapid determination of 90Sr impurities in freshly "generator eluted" 90Y for radiopharmaceutical preparation

Mauro L. Bonardi, Luigi Martano, Flavia Groppi, Marco Chinol

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

90Y is one of the most useful radionuclides for radioimmunotherapeutic applications and has a half-life (t1/2=64.14 h) suitable for most therapeutic applications, beta particles of high energy and decays to a stable daughter. It is significant that 90Y is available conveniently and inexpensively from a radionuclide "generator" by decay of its parent, 90Sr. Nevertheless, current and planned clinical applications with [90Y] labelled compounds employ activity levels that cannot be readily obtained from an in-house generator, but from commercial sources. We have evaluated Eichrom's Sr-resin, either as an "in-house" generator or as a fast QC method for analysis of 90Y solutions. In particular, for the development as a generator, we investigated the percentage of the radio-Sr in the first 8 M HNO3 eluate: in this fraction the concentration of 90Sr must be smaller than 10-5% (recommendations of the International Commission on Radiological Protection). For evaluation as a rapid QC method, we analyzed the concentration of 90Y in all the fractions containing "only" radio-Sr: 90Y should not be present in these eluates. After the collection of β- and γ spectra and analysis of them, we concluded that commercial Sr-resin minicolumn cannot give us the results expected; we developed an in-house system loaded with 4 mL of Sr-resin which gave better results as a generator and a rapid QC method.

Original languageEnglish
Pages (from-to)1874-1877
Number of pages4
JournalApplied Radiation and Isotopes
Volume67
Issue number10
DOIs
Publication statusPublished - Oct 2009

Fingerprint

generators
impurities
preparation
resins
radioactive isotopes
beta particles
decay
recommendations
half life
evaluation
energy

Keywords

  • Sr contamination
  • Sr/Y generator
  • Y for human use
  • Extraction method

ASJC Scopus subject areas

  • Radiation

Cite this

Rapid determination of 90Sr impurities in freshly "generator eluted" 90Y for radiopharmaceutical preparation. / Bonardi, Mauro L.; Martano, Luigi; Groppi, Flavia; Chinol, Marco.

In: Applied Radiation and Isotopes, Vol. 67, No. 10, 10.2009, p. 1874-1877.

Research output: Contribution to journalArticle

@article{eb2bdb579d204d37bb669be718f04fc3,
title = "Rapid determination of 90Sr impurities in freshly {"}generator eluted{"} 90Y for radiopharmaceutical preparation",
abstract = "90Y is one of the most useful radionuclides for radioimmunotherapeutic applications and has a half-life (t1/2=64.14 h) suitable for most therapeutic applications, beta particles of high energy and decays to a stable daughter. It is significant that 90Y is available conveniently and inexpensively from a radionuclide {"}generator{"} by decay of its parent, 90Sr. Nevertheless, current and planned clinical applications with [90Y] labelled compounds employ activity levels that cannot be readily obtained from an in-house generator, but from commercial sources. We have evaluated Eichrom's Sr-resin, either as an {"}in-house{"} generator or as a fast QC method for analysis of 90Y solutions. In particular, for the development as a generator, we investigated the percentage of the radio-Sr in the first 8 M HNO3 eluate: in this fraction the concentration of 90Sr must be smaller than 10-5{\%} (recommendations of the International Commission on Radiological Protection). For evaluation as a rapid QC method, we analyzed the concentration of 90Y in all the fractions containing {"}only{"} radio-Sr: 90Y should not be present in these eluates. After the collection of β- and γ spectra and analysis of them, we concluded that commercial Sr-resin minicolumn cannot give us the results expected; we developed an in-house system loaded with 4 mL of Sr-resin which gave better results as a generator and a rapid QC method.",
keywords = "Sr contamination, Sr/Y generator, Y for human use, Extraction method",
author = "Bonardi, {Mauro L.} and Luigi Martano and Flavia Groppi and Marco Chinol",
year = "2009",
month = "10",
doi = "10.1016/j.apradiso.2009.06.005",
language = "English",
volume = "67",
pages = "1874--1877",
journal = "Applied Radiation and Isotopes",
issn = "0969-8043",
publisher = "Elsevier Limited",
number = "10",

}

TY - JOUR

T1 - Rapid determination of 90Sr impurities in freshly "generator eluted" 90Y for radiopharmaceutical preparation

AU - Bonardi, Mauro L.

AU - Martano, Luigi

AU - Groppi, Flavia

AU - Chinol, Marco

PY - 2009/10

Y1 - 2009/10

N2 - 90Y is one of the most useful radionuclides for radioimmunotherapeutic applications and has a half-life (t1/2=64.14 h) suitable for most therapeutic applications, beta particles of high energy and decays to a stable daughter. It is significant that 90Y is available conveniently and inexpensively from a radionuclide "generator" by decay of its parent, 90Sr. Nevertheless, current and planned clinical applications with [90Y] labelled compounds employ activity levels that cannot be readily obtained from an in-house generator, but from commercial sources. We have evaluated Eichrom's Sr-resin, either as an "in-house" generator or as a fast QC method for analysis of 90Y solutions. In particular, for the development as a generator, we investigated the percentage of the radio-Sr in the first 8 M HNO3 eluate: in this fraction the concentration of 90Sr must be smaller than 10-5% (recommendations of the International Commission on Radiological Protection). For evaluation as a rapid QC method, we analyzed the concentration of 90Y in all the fractions containing "only" radio-Sr: 90Y should not be present in these eluates. After the collection of β- and γ spectra and analysis of them, we concluded that commercial Sr-resin minicolumn cannot give us the results expected; we developed an in-house system loaded with 4 mL of Sr-resin which gave better results as a generator and a rapid QC method.

AB - 90Y is one of the most useful radionuclides for radioimmunotherapeutic applications and has a half-life (t1/2=64.14 h) suitable for most therapeutic applications, beta particles of high energy and decays to a stable daughter. It is significant that 90Y is available conveniently and inexpensively from a radionuclide "generator" by decay of its parent, 90Sr. Nevertheless, current and planned clinical applications with [90Y] labelled compounds employ activity levels that cannot be readily obtained from an in-house generator, but from commercial sources. We have evaluated Eichrom's Sr-resin, either as an "in-house" generator or as a fast QC method for analysis of 90Y solutions. In particular, for the development as a generator, we investigated the percentage of the radio-Sr in the first 8 M HNO3 eluate: in this fraction the concentration of 90Sr must be smaller than 10-5% (recommendations of the International Commission on Radiological Protection). For evaluation as a rapid QC method, we analyzed the concentration of 90Y in all the fractions containing "only" radio-Sr: 90Y should not be present in these eluates. After the collection of β- and γ spectra and analysis of them, we concluded that commercial Sr-resin minicolumn cannot give us the results expected; we developed an in-house system loaded with 4 mL of Sr-resin which gave better results as a generator and a rapid QC method.

KW - Sr contamination

KW - Sr/Y generator

KW - Y for human use

KW - Extraction method

UR - http://www.scopus.com/inward/record.url?scp=68949197250&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=68949197250&partnerID=8YFLogxK

U2 - 10.1016/j.apradiso.2009.06.005

DO - 10.1016/j.apradiso.2009.06.005

M3 - Article

C2 - 19628401

AN - SCOPUS:68949197250

VL - 67

SP - 1874

EP - 1877

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

SN - 0969-8043

IS - 10

ER -