Rapid determination of 90Sr impurities in freshly "generator eluted" 90Y for radiopharmaceutical preparation

Mauro L. Bonardi, Luigi Martano, Flavia Groppi, Marco Chinol

Research output: Contribution to journalArticlepeer-review

Abstract

90Y is one of the most useful radionuclides for radioimmunotherapeutic applications and has a half-life (t1/2=64.14 h) suitable for most therapeutic applications, beta particles of high energy and decays to a stable daughter. It is significant that 90Y is available conveniently and inexpensively from a radionuclide "generator" by decay of its parent, 90Sr. Nevertheless, current and planned clinical applications with [90Y] labelled compounds employ activity levels that cannot be readily obtained from an in-house generator, but from commercial sources. We have evaluated Eichrom's Sr-resin, either as an "in-house" generator or as a fast QC method for analysis of 90Y solutions. In particular, for the development as a generator, we investigated the percentage of the radio-Sr in the first 8 M HNO3 eluate: in this fraction the concentration of 90Sr must be smaller than 10-5% (recommendations of the International Commission on Radiological Protection). For evaluation as a rapid QC method, we analyzed the concentration of 90Y in all the fractions containing "only" radio-Sr: 90Y should not be present in these eluates. After the collection of β- and γ spectra and analysis of them, we concluded that commercial Sr-resin minicolumn cannot give us the results expected; we developed an in-house system loaded with 4 mL of Sr-resin which gave better results as a generator and a rapid QC method.

Original languageEnglish
Pages (from-to)1874-1877
Number of pages4
JournalApplied Radiation and Isotopes
Volume67
Issue number10
DOIs
Publication statusPublished - Oct 2009

Keywords

  • Sr contamination
  • Sr/Y generator
  • Y for human use
  • Extraction method

ASJC Scopus subject areas

  • Radiation

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