Abstract
90Y is one of the most useful radionuclides for radioimmunotherapeutic applications and has a half-life (t1/2=64.14 h) suitable for most therapeutic applications, beta particles of high energy and decays to a stable daughter. It is significant that 90Y is available conveniently and inexpensively from a radionuclide "generator" by decay of its parent, 90Sr. Nevertheless, current and planned clinical applications with [90Y] labelled compounds employ activity levels that cannot be readily obtained from an in-house generator, but from commercial sources. We have evaluated Eichrom's Sr-resin, either as an "in-house" generator or as a fast QC method for analysis of 90Y solutions. In particular, for the development as a generator, we investigated the percentage of the radio-Sr in the first 8 M HNO3 eluate: in this fraction the concentration of 90Sr must be smaller than 10-5% (recommendations of the International Commission on Radiological Protection). For evaluation as a rapid QC method, we analyzed the concentration of 90Y in all the fractions containing "only" radio-Sr: 90Y should not be present in these eluates. After the collection of β- and γ spectra and analysis of them, we concluded that commercial Sr-resin minicolumn cannot give us the results expected; we developed an in-house system loaded with 4 mL of Sr-resin which gave better results as a generator and a rapid QC method.
| Original language | English |
|---|---|
| Pages (from-to) | 1874-1877 |
| Number of pages | 4 |
| Journal | Applied Radiation and Isotopes |
| Volume | 67 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 2009 |
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Keywords
- Sr contamination
- Sr/Y generator
- Y for human use
- Extraction method
ASJC Scopus subject areas
- Radiation
Cite this
Rapid determination of 90Sr impurities in freshly "generator eluted" 90Y for radiopharmaceutical preparation. / Bonardi, Mauro L.; Martano, Luigi; Groppi, Flavia; Chinol, Marco.
In: Applied Radiation and Isotopes, Vol. 67, No. 10, 10.2009, p. 1874-1877.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Rapid determination of 90Sr impurities in freshly "generator eluted" 90Y for radiopharmaceutical preparation
AU - Bonardi, Mauro L.
AU - Martano, Luigi
AU - Groppi, Flavia
AU - Chinol, Marco
PY - 2009/10
Y1 - 2009/10
N2 - 90Y is one of the most useful radionuclides for radioimmunotherapeutic applications and has a half-life (t1/2=64.14 h) suitable for most therapeutic applications, beta particles of high energy and decays to a stable daughter. It is significant that 90Y is available conveniently and inexpensively from a radionuclide "generator" by decay of its parent, 90Sr. Nevertheless, current and planned clinical applications with [90Y] labelled compounds employ activity levels that cannot be readily obtained from an in-house generator, but from commercial sources. We have evaluated Eichrom's Sr-resin, either as an "in-house" generator or as a fast QC method for analysis of 90Y solutions. In particular, for the development as a generator, we investigated the percentage of the radio-Sr in the first 8 M HNO3 eluate: in this fraction the concentration of 90Sr must be smaller than 10-5% (recommendations of the International Commission on Radiological Protection). For evaluation as a rapid QC method, we analyzed the concentration of 90Y in all the fractions containing "only" radio-Sr: 90Y should not be present in these eluates. After the collection of β- and γ spectra and analysis of them, we concluded that commercial Sr-resin minicolumn cannot give us the results expected; we developed an in-house system loaded with 4 mL of Sr-resin which gave better results as a generator and a rapid QC method.
AB - 90Y is one of the most useful radionuclides for radioimmunotherapeutic applications and has a half-life (t1/2=64.14 h) suitable for most therapeutic applications, beta particles of high energy and decays to a stable daughter. It is significant that 90Y is available conveniently and inexpensively from a radionuclide "generator" by decay of its parent, 90Sr. Nevertheless, current and planned clinical applications with [90Y] labelled compounds employ activity levels that cannot be readily obtained from an in-house generator, but from commercial sources. We have evaluated Eichrom's Sr-resin, either as an "in-house" generator or as a fast QC method for analysis of 90Y solutions. In particular, for the development as a generator, we investigated the percentage of the radio-Sr in the first 8 M HNO3 eluate: in this fraction the concentration of 90Sr must be smaller than 10-5% (recommendations of the International Commission on Radiological Protection). For evaluation as a rapid QC method, we analyzed the concentration of 90Y in all the fractions containing "only" radio-Sr: 90Y should not be present in these eluates. After the collection of β- and γ spectra and analysis of them, we concluded that commercial Sr-resin minicolumn cannot give us the results expected; we developed an in-house system loaded with 4 mL of Sr-resin which gave better results as a generator and a rapid QC method.
KW - Sr contamination
KW - Sr/Y generator
KW - Y for human use
KW - Extraction method
UR - http://www.scopus.com/inward/record.url?scp=68949197250&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=68949197250&partnerID=8YFLogxK
U2 - 10.1016/j.apradiso.2009.06.005
DO - 10.1016/j.apradiso.2009.06.005
M3 - Article
C2 - 19628401
AN - SCOPUS:68949197250
VL - 67
SP - 1874
EP - 1877
JO - Applied Radiation and Isotopes
JF - Applied Radiation and Isotopes
SN - 0969-8043
IS - 10
ER -