Rapid in vivo assay of mouse natural killer cell activity

C. Riccardi, P. Puccetti, A. Santoni, R. B. Herberman

Research output: Contribution to journalArticlepeer-review


A rapid elimination of tumor cells from some organs was detected in mice following iv injection of tumor cells labeled in vitro with [125I]5-iodo-2'-deoxyuridine. Recovery of radioactivity in different organs (spleen, liver, and lungs) was reduced in mice with high natural killer (NK) cell reactivity in their spleens, as measured in vitro by concomitant short-term 51Cr release assay. Considerable parallelism between in vitro and in vivo reactivity against to mouse lymphomas and a human myeloid cell line was found in mice of different strains and ages. Similarly, various immunopharmacologic treatments had comparable effects on in vitro and in vivo reactivities. These findings are consistent with the hypothesis that rapid cytolysis of tumor cells occurred in vivo and that NK cells played a major role in their elimination.

Original languageEnglish
Pages (from-to)1041-1045
Number of pages5
JournalJournal of the National Cancer Institute
Issue number4
Publication statusPublished - 1979

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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