Rapid onset of bronchodilation with formoterol/beclomethasone Modulite and formoterol/budesonide Turbuhaler as compared to formoterol alone in patients with COPD

Mario Cazzola, Franco Pasqua, Luigi Ferri, Gianluca Biscione, Vittorio Cardaci, Maria Gabriella Matera

Research output: Contribution to journalArticlepeer-review

Abstract

In the present study, we examined whether there is a difference in the onset of bronchodilatation between formoterol/beclomethasone 12/200 μg Modulite and formoterol/budesonide 9/320 μg Turbuhaler in patients with COPD. We enrolled 28 patients with stable COPD. Both formoterol/beclomethasone and formoterol/budesonide elicited a larger mean FEV 1-AUC 0-15min than formoterol alone, whereas there was no significant difference between their FEV 1-AUC 0-15min. Also the change in FEV 1 15 min after inhalation of formoterol/beclomethasone combination or formoterol/budesonide combination was greater than that induced by formoterol alone. This study confirms the rapid effect of the inhaled corticosteroid component when combined with formoterol and indicates that the onset of bronchodilation of formoterol/beclomethasone Modulite and formoterol/budesonide Turbuhaler are similar and greater than formoterol alone in patients with COPD.

Original languageEnglish
Pages (from-to)118-122
Number of pages5
JournalPulmonary Pharmacology and Therapeutics
Volume24
Issue number1
DOIs
Publication statusPublished - Feb 2011

Keywords

  • Beclomethasone
  • Budesonide
  • COPD
  • Formoterol
  • Onset of action

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Pharmacology (medical)
  • Biochemistry, medical

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