Rapid prototyping of nano- and micro-patterned substrates for the control of cell neuritogenesis by topographic and chemical cues

Ajay V. Singh, Lasma Gailite, Varun Vyas, Cristina Lenardi, Stefania Forti, Michela Matteoli, Paolo Milani

Research output: Contribution to journalArticle

Abstract

Rapid prototyping of titania substrates with micro and nanofeatures is obtained by combining nanosphere lithography with supersonic cluster beam deposition on protein-functionalized glass supports. The proliferation and differentiation of PC12 cells were studied on these substrates. The facile control and modification of the substrate structure at the micro- and nanoscale allowed us to characterize the role of functional and structural features on neuritogenesis and to control this phenomenon by identifying the optimal topography.

Original languageEnglish
Pages (from-to)892-899
Number of pages8
JournalMaterials Science and Engineering C
Volume31
Issue number5
DOIs
Publication statusPublished - Jul 20 2011

Keywords

  • Cell culture
  • Micropatterning
  • Nanotopography
  • Neural network
  • Titanium oxide

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering
  • Mechanics of Materials

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