Rapid prototyping of nano- and micro-patterned substrates for the control of cell neuritogenesis by topographic and chemical cues

Ajay V. Singh, Lasma Gailite, Varun Vyas, Cristina Lenardi, Stefania Forti, Michela Matteoli, Paolo Milani

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Rapid prototyping of titania substrates with micro and nanofeatures is obtained by combining nanosphere lithography with supersonic cluster beam deposition on protein-functionalized glass supports. The proliferation and differentiation of PC12 cells were studied on these substrates. The facile control and modification of the substrate structure at the micro- and nanoscale allowed us to characterize the role of functional and structural features on neuritogenesis and to control this phenomenon by identifying the optimal topography.

Original languageEnglish
Pages (from-to)892-899
Number of pages8
JournalMaterials Science and Engineering C
Volume31
Issue number5
DOIs
Publication statusPublished - Jul 20 2011

Fingerprint

rapid prototyping
cues
Rapid prototyping
Substrates
cells
Nanospheres
microbalances
Topography
Lithography
topography
lithography
titanium
Titanium
proteins
Proteins
Glass
glass

Keywords

  • Cell culture
  • Micropatterning
  • Nanotopography
  • Neural network
  • Titanium oxide

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering
  • Mechanics of Materials

Cite this

Rapid prototyping of nano- and micro-patterned substrates for the control of cell neuritogenesis by topographic and chemical cues. / Singh, Ajay V.; Gailite, Lasma; Vyas, Varun; Lenardi, Cristina; Forti, Stefania; Matteoli, Michela; Milani, Paolo.

In: Materials Science and Engineering C, Vol. 31, No. 5, 20.07.2011, p. 892-899.

Research output: Contribution to journalArticle

Singh, Ajay V. ; Gailite, Lasma ; Vyas, Varun ; Lenardi, Cristina ; Forti, Stefania ; Matteoli, Michela ; Milani, Paolo. / Rapid prototyping of nano- and micro-patterned substrates for the control of cell neuritogenesis by topographic and chemical cues. In: Materials Science and Engineering C. 2011 ; Vol. 31, No. 5. pp. 892-899.
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