Rapid suppression of bone resorption and parathyroid hormone secretion by acute oral administration of calcium in healthy adult men

Sergio Ortolani, A. Scotti, R. Cherubini

Research output: Contribution to journalArticle

Abstract

Acute effects of oral calcium supplementation have been studied mainly in pre- and post-menopausal women, whereas very few data concerning men are available. We investigated the effects of 1.2 g of oral calcium administered for 4 days in 18 healthy young men. The day before the first calcium dosing (day -1) and the day of the last calcium dosing (day 4) total and ionized serum calcium and intact PTH were measured at multiple time-points up to 24 h; calcium, C-terminal telopeptide (CTX), pyridinoline (PYD) and deoxypyridinoline (DPD) were measured in urine collected every six h. On day 4, total and ionized serum calcium increased during the 6 h following oral calcium: the maximum increase over baseline was 5.04 and 7.4% respectively, occurring after 2.9±1.9 h (mean±SD) and 2.6±0.9 h. The AUC was significantly higher on day 4 than on day -1 for both total serum calcium (+4.6%, p

Original languageEnglish
Pages (from-to)353-358
Number of pages6
JournalJournal of Endocrinological Investigation
Volume26
Issue number4
Publication statusPublished - Apr 2003

Keywords

  • Bone resorption
  • C-terminal telopeptide of type I collagen (CTX)
  • Calcium supplementation
  • Deoxy-pyridinolone
  • Healthy men
  • Osteoporosis
  • Parathyroid hormone
  • Pharmacodynamic
  • Pyridinoline

ASJC Scopus subject areas

  • Endocrinology

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