Rare cancers in childhood and adolescence in Brazil: First report of data from 19 population-based cancer registries

Nathalie V. Balmant, Rejane de Souza Reis, Marceli de Oliveira Santos, Beatriz de Camargo, Gemma Gatta

Research output: Contribution to journalArticlepeer-review


Background: Rare childhood cancer is challenging to define. The Italian Pediatric Rare Tumor (TREP) Study considers rare tumors to include solid malignancies characterized by an annual incidence rate of <2 cases per 1 million and not enrolled in clinical trials. The objective of the current study was to analyze the population incidence rate of rare tumors among children and adolescents (those aged birth-19 years) in Brazil. Methods: Incidence data were obtained from 19 population-based cancer registries covering the 5 geographic regions in Brazil. Newly diagnosed cases were selected according to the TREP definition, using the International Classification of Diseases for Oncology. To calculate the crude incidence rate, the numbers of incident children and adolescents with a specific rare cancer were divided by the corresponding person-years lived for the population aged <20 years during the same period. Results: Two tumors had an incidence rate that was >2 cases per 1 million (thyroid and skin cancers) in adolescents only. Several tumors demonstrated variations in incidence across the Brazilian regions. Adrenocortical carcinoma had a high incidence rate (4 cases per 1 million) in the south region among children aged <10 years. Thyroid and skin carcinoma had higher incidence rates in the midwest, southeast, and south regions. Conclusions: Due to the extraordinary rarity of these events, networking is important for improving basic research, clinical studies, and trials. Centralization of diagnosis is the only way to improve the diagnosis and treatment of children affected by these rare diseases. The registration and surveillance of rare pediatric cancers are crucial from a public health point of view, and therefore the quality of registration has to be improved.

Original languageEnglish
Pages (from-to)2638-2646
Number of pages9
Issue number15
Publication statusPublished - Aug 1 2019


  • adolescents
  • Brazil
  • childhood
  • population-based registries
  • rare tumors

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


Dive into the research topics of 'Rare cancers in childhood and adolescence in Brazil: First report of data from 19 population-based cancer registries'. Together they form a unique fingerprint.

Cite this