Rare expression of T-cell markers in classical Hodgkin's lymphoma

Alexandar Tzankov, Caroline Bourgau, Alexandra Kaiser, Annette Zimpfer, Robert Maurer, Stefano A. Pileri, Philip Went, Stephan Dirnhofer

Research output: Contribution to journalArticle

Abstract

Hodgkin's and Reed-Sternberg cells of classical Hodgkin's lymphoma are primarily of B-cell origin, although there are instances of T-cell antigen expression suggesting T-cell origin. We comprehensively analyzed expression of various T-cell antigens in 259 classical Hodgkin's lymphoma cases using the tissue microarray technique. Expression of the T-cell antigens CD2, CD3, CD4, CD5, CD7 and CD8 was assessed by immunohistochemistry. Hodgkin's and Reed-Sternberg cells of T-cell marker-positive cases were microdissected and analyzed by a multiplex polymerase chain reaction for clonal immunoglobulin heavy chain- and T-cell receptor γ gene rearrangements. In all, 12 cases (5%) expressed at least one T-cell marker in the following order: CD2 in 11 cases, CD4 in five, CD3 in two, and CD5 and CD8 in one case each; there were no CD7-positive cases, and five cases (2%) expressed more than one T-cell antigen. In positive cases, a mean fraction of 40% of the Hodgkin's and Reed-Sternberg cells (range 20-100%) expressed the analyzed T-cell markers. Two cases (

Original languageEnglish
Pages (from-to)1542-1549
Number of pages8
JournalModern Pathology
Volume18
Issue number12
DOIs
Publication statusPublished - Dec 2005

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ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Tzankov, A., Bourgau, C., Kaiser, A., Zimpfer, A., Maurer, R., Pileri, S. A., Went, P., & Dirnhofer, S. (2005). Rare expression of T-cell markers in classical Hodgkin's lymphoma. Modern Pathology, 18(12), 1542-1549. https://doi.org/10.1038/modpathol.3800473