Rare expression of T-cell markers in classical Hodgkin's lymphoma

Alexandar Tzankov, Caroline Bourgau, Alexandra Kaiser, Annette Zimpfer, Robert Maurer, Stefano A. Pileri, Philip Went, Stephan Dirnhofer

Research output: Contribution to journalArticle

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Abstract

Hodgkin's and Reed-Sternberg cells of classical Hodgkin's lymphoma are primarily of B-cell origin, although there are instances of T-cell antigen expression suggesting T-cell origin. We comprehensively analyzed expression of various T-cell antigens in 259 classical Hodgkin's lymphoma cases using the tissue microarray technique. Expression of the T-cell antigens CD2, CD3, CD4, CD5, CD7 and CD8 was assessed by immunohistochemistry. Hodgkin's and Reed-Sternberg cells of T-cell marker-positive cases were microdissected and analyzed by a multiplex polymerase chain reaction for clonal immunoglobulin heavy chain- and T-cell receptor γ gene rearrangements. In all, 12 cases (5%) expressed at least one T-cell marker in the following order: CD2 in 11 cases, CD4 in five, CD3 in two, and CD5 and CD8 in one case each; there were no CD7-positive cases, and five cases (2%) expressed more than one T-cell antigen. In positive cases, a mean fraction of 40% of the Hodgkin's and Reed-Sternberg cells (range 20-100%) expressed the analyzed T-cell markers. Two cases (

Original languageEnglish
Pages (from-to)1542-1549
Number of pages8
JournalModern Pathology
Volume18
Issue number12
DOIs
Publication statusPublished - Dec 2005

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Hodgkin Disease
T-Lymphocytes
Viral Tumor Antigens
Reed-Sternberg Cells
T-Lymphocyte Gene Rearrangement
T-Cell Receptor Genes
Immunoglobulin Heavy Chains
Multiplex Polymerase Chain Reaction
B-Lymphocytes
Immunohistochemistry

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Tzankov, A., Bourgau, C., Kaiser, A., Zimpfer, A., Maurer, R., Pileri, S. A., ... Dirnhofer, S. (2005). Rare expression of T-cell markers in classical Hodgkin's lymphoma. Modern Pathology, 18(12), 1542-1549. https://doi.org/10.1038/modpathol.3800473

Rare expression of T-cell markers in classical Hodgkin's lymphoma. / Tzankov, Alexandar; Bourgau, Caroline; Kaiser, Alexandra; Zimpfer, Annette; Maurer, Robert; Pileri, Stefano A.; Went, Philip; Dirnhofer, Stephan.

In: Modern Pathology, Vol. 18, No. 12, 12.2005, p. 1542-1549.

Research output: Contribution to journalArticle

Tzankov, A, Bourgau, C, Kaiser, A, Zimpfer, A, Maurer, R, Pileri, SA, Went, P & Dirnhofer, S 2005, 'Rare expression of T-cell markers in classical Hodgkin's lymphoma', Modern Pathology, vol. 18, no. 12, pp. 1542-1549. https://doi.org/10.1038/modpathol.3800473
Tzankov A, Bourgau C, Kaiser A, Zimpfer A, Maurer R, Pileri SA et al. Rare expression of T-cell markers in classical Hodgkin's lymphoma. Modern Pathology. 2005 Dec;18(12):1542-1549. https://doi.org/10.1038/modpathol.3800473
Tzankov, Alexandar ; Bourgau, Caroline ; Kaiser, Alexandra ; Zimpfer, Annette ; Maurer, Robert ; Pileri, Stefano A. ; Went, Philip ; Dirnhofer, Stephan. / Rare expression of T-cell markers in classical Hodgkin's lymphoma. In: Modern Pathology. 2005 ; Vol. 18, No. 12. pp. 1542-1549.
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