Rare HVR1-HCV genotype lb variants in patients with B Non Hodgkin's Lymphoma. Comparison with viral sequences detected in cases of lymphoproliferative disorders and B cell compartmentalisation

Stefano Dettori, Claudio Argentini, Fabrizio Marcucci, Enea Spada, Paola Chionne, Angela Candido, Elisabetta Madonna, Anna Rita Ciccaglione, Elvira Bianco, Emilio Iannitto, Pellegrino Musto, Vincenzo Liso, Amalia De Renzo, Livio Pagano, Grazia Nieddu, Alessandro Pulsoni, Alfonso Mele, Maria Rapicetta

Research output: Contribution to journalArticle

Abstract

We compared the E2-HVR1 region in HCV-1b positive B-NHL cases from a multicenter study with sequences from studies related to lymphoproliferative disorders and B cell compartmentalisation. We found rare and unique mutations both in B-NHL isolates and in cases with lymphoproliferative disorders and lymphocyte infection. These rare mutations could have an important effect on HVR1 region and, as a consequence, on the binding of E2 on CD81, with a possible implication for both antigenic stimulation and HCV entry. In conclusion, the HCV predominants circulating in B-NHL cases seem to be associated with clonal selection of rare variants.

Original languageEnglish
Pages (from-to)265-270
Number of pages6
JournalNew Microbiologica
Volume30
Issue number3
Publication statusPublished - Jul 2007

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Keywords

  • HCV
  • HVR1
  • Non Hodgkin's lymphoma
  • Viral variabilita
  • Viral variants

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

Cite this

Dettori, S., Argentini, C., Marcucci, F., Spada, E., Chionne, P., Candido, A., Madonna, E., Ciccaglione, A. R., Bianco, E., Iannitto, E., Musto, P., Liso, V., De Renzo, A., Pagano, L., Nieddu, G., Pulsoni, A., Mele, A., & Rapicetta, M. (2007). Rare HVR1-HCV genotype lb variants in patients with B Non Hodgkin's Lymphoma. Comparison with viral sequences detected in cases of lymphoproliferative disorders and B cell compartmentalisation. New Microbiologica, 30(3), 265-270.