Rare thyroid malignancies in Europe: Data from the information network on rare cancers in Europe (RARECAREnet)

Laura Locati, Stefano Cavalieri, Luigino Dal Maso, Susanna Busco, Lesley Ann Anderson, Laura Botta, Maria José Bento, Marià Carulla, Maria Dolores Chirlaque López, Mario Fusco, Marcela Guevara, Kaire Innos, Tom Børge Johannesen, Rita Micallef, Pamela Minicozzi, Chiara Panato, Dafina Petrova, Jordi Rubio-Casadevall, Giedre Smailyte, Maria Francesca VitaleAnnalisa Trama

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Limited information is available on the incidence of rare thyroid cancer (TC) subtypes: anaplastic (ATC) and medullary (MTC). The aim of this study was to describe incidence variations and trends across European countries of all TC subtypes. Materials and methods: We used the RARECAREnet database including 80721 TC incident cases in the period 2000–2007 from 77 population-based cancer registries (CRs) in Europe. In the trend analyses, we included 68890 TC cases from 53 CRs with at least 6 years of incidence data in the years 2000–2007. Results: In Europe age-standardised incidence rates (ASR) in women were <0.3/100,000 for MTC and ATC whereas ASR were 5.3/100,000 for papillary thyroid cancer (PTC) and 1.1/100,000 for follicular TC (FTC). Corresponding ASRs in men were <0.2/100,000 for MTC and ATC, 1.5 for PTC and 0.4 for FTC. Across countries and in both sexes the incidence of FTC and MTC was moderately correlated (r ~ 0.5) with that of PTC, while a less marked correlation (r < 0.4) emerged for ATC ASRs. The changes of the PTC ASRs across countries and time were weakly (r < 0.3) or moderately (r ~ 0.5) correlated to the changes of the other subtypes for both sexes. Conclusion: The huge increase and heterogeneity between countries of PTC incidence has a small influence on the trends and variations of MTC and ATC in Europe. Large-scale epidemiological and clinical registry-based studies are warranted to increase knowledge about the rarest TC subtypes. This information would be fundamental for the design of new clinical trials and for inference.

Original languageEnglish
Article number104766
Number of pages8
JournalOral Oncology
Volume108
DOIs
Publication statusPublished - Sep 2020

Keywords

  • Anaplastic thyroid cancer
  • Cancer registries
  • Epidemiology
  • Incidence
  • Medullary thyroid cancer
  • Thyroid cancer

ASJC Scopus subject areas

  • Oral Surgery
  • Oncology
  • Cancer Research

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