Rare tumors in children: Progress through collaboration

Alberto S. Pappo, Wayne L. Furman, Kris A. Schultz, Andrea Ferrari, Lee Helman, Mark D. Krailo

Research output: Contribution to journalArticlepeer-review


Rare pediatric tumors account for approximately 10% of all childhood cancers, which in themselves are a rare entity. The diverse histologies and clinical behaviors of rare pediatric tumors pose challenges to the investigation of their biologic and clinical features. National and international cooperative groups such as the Rare Tumor Committee of the Children's Oncology Group, Rare Tumors in Pediatric Age Project, and European Cooperative Study Group for Pediatric Rare Tumors have developed several initiatives to advance knowledge about rare pediatric cancers. However, these programs have been only partially effective, necessitating the development of alternative mechanisms to study these challenging diseases. In this article, we review the current national and international collaborative strategies to study rare pediatric cancers and alternative methods under exploration to enhance those efforts, such as independent registries and disease-specific, National Cancer Institute-sponsored clinics.

Original languageEnglish
Pages (from-to)3047-3054
Number of pages8
JournalJournal of Clinical Oncology
Issue number27
Publication statusPublished - Sep 20 2015

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)


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