Ras-related and MAPK signalling in neuronal plasticity and memory formation

C. Mazzucchelli, R. Brambilla

Research output: Contribution to journalArticlepeer-review


Ras-related guanosine triphosphatases (GTPases) couple receptor activity to a number of intracellular signalling events culminating in the control of cell morphology and gene transcription. In culture cells, the best-understood Ras-dependent signalling pathway involves the mitogen-activated protein kinase/extracellular-regulated kinase (MAPK/ERK) cascade. A growing body of evidence has recently been accumulating to suggest a crucial role of Ras and MAPK signalling in neuronal functions connected to synaptic plasticity. In the present review article we discuss the experimental basis supporting the notion that the Ras/MAPK pathway interacts with other synaptic mechanisms to regulate invertebrate and vertebrate behavioural responses such as those implicated in learning and memory processes.

Original languageEnglish
Pages (from-to)604-611
Number of pages8
JournalCellular and Molecular Life Sciences
Issue number4
Publication statusPublished - 2000


  • Hippocampus
  • Learning and memory
  • Ras/MAPK signalling
  • Synaptic plasticity

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cell Biology


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