Rasagiline for dysexecutive symptoms during wearing-off in Parkinson’s disease: a pilot study

Domiziana Rinaldi, Francesca Assogna, Michela Sforza, Stefania Tagliente, Francesco E. Pontieri

Research output: Contribution to journalArticlepeer-review


Wearing-off refers to the predictable worsening of motor and sometimes non-motor symptoms of Parkinson’s disease occurring at the end of levodopa dose that improves with the next drug dose. Here, we investigated the efficacy of rasagiline on executive functions at the end of levodopa dose in patients displaying symptoms of wearing-off. Rasagiline was well-tolerated and produced a significant improvement at the Frontal Assessment Battery, together with improvement of motor symptoms at the end of levodopa dose. These results suggest that treatment of motor symptoms of wearing-off with rasagiline may be accompanied by improvement of executive functions, and further support the need for optimizing dopamine replacement therapy in fluctuating Parkinson’s disease patients.

Original languageEnglish
Pages (from-to)141-143
Number of pages3
JournalNeurological Sciences
Issue number1
Publication statusE-pub ahead of print - Sep 27 2017


  • Cognition
  • Frontal Assessment Battery
  • Parkinson’s disease
  • Rasagiline
  • Wearing-off

ASJC Scopus subject areas

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health


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