Rasagiline for dysexecutive symptoms during wearing-off in Parkinson’s disease: a pilot study

Domiziana Rinaldi; Francesca Assogna; Michela Sforza; Stefania Tagliente; Francesco E. Pontieri

doi:10.1007/s10072-017-3123-2

Rasagiline for dysexecutive symptoms during wearing-off in Parkinson’s disease: a pilot study

Domiziana Rinaldi, Francesca Assogna, Michela Sforza, Stefania Tagliente, Francesco E. Pontieri

Fondazione Santa Lucia

Research output: Contribution to journal › Article

Abstract

Wearing-off refers to the predictable worsening of motor and sometimes non-motor symptoms of Parkinson’s disease occurring at the end of levodopa dose that improves with the next drug dose. Here, we investigated the efficacy of rasagiline on executive functions at the end of levodopa dose in patients displaying symptoms of wearing-off. Rasagiline was well-tolerated and produced a significant improvement at the Frontal Assessment Battery, together with improvement of motor symptoms at the end of levodopa dose. These results suggest that treatment of motor symptoms of wearing-off with rasagiline may be accompanied by improvement of executive functions, and further support the need for optimizing dopamine replacement therapy in fluctuating Parkinson’s disease patients.

Original language	English
Pages (from-to)	141-143
Number of pages	3
Journal	Neurological Sciences
Volume	39
Issue number	1
DOIs	https://doi.org/10.1007/s10072-017-3123-2
Publication status	E-pub ahead of print - Sep 27 2017

Keywords

Cognition
Frontal Assessment Battery
Parkinson’s disease
Rasagiline
Wearing-off

ASJC Scopus subject areas

Dermatology
Clinical Neurology
Psychiatry and Mental health

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Rinaldi, D., Assogna, F., Sforza, M., Tagliente, S., & Pontieri, F. E. (2017). Rasagiline for dysexecutive symptoms during wearing-off in Parkinson’s disease: a pilot study. Neurological Sciences, 39(1), 141-143. https://doi.org/10.1007/s10072-017-3123-2

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