Rasmussen's encephalitis: Early characteristics allow diagnosis

Tiziana Granata, G. Gobbi, R. Spreafico, F. Vigevano, G. Capovilla, F. Ragona, E. Freri, L. Chiapparini, P. Bernasconi, L. Giordano, G. Bertani, M. Casazza, B. Dalla Bernardina, L. Fusco

Research output: Contribution to journalArticle

Abstract

Objective: To identify early manifestations of Rasmussen encephalitis (RE) that can prompt early and reasonably secure diagnosis, allowing medical or surgical therapies at an early stage when they may be more effective in slowing the disease. Methods: The authors studied 12 patients with clinical and neuropathologic diagnosis of RE, followed from disease onset, assessing clinical history, imaging, and EEG and focusing on early characteristics. Anti-GluR3 antibody assays were also considered in 11 patients. Results: By 4 months from first symptoms, all cases had 1) refractory focal seizures with a predominant motor component, 2) slow focal activity on EEG contralateral to the motor manifestations, and 3) focal contralateral white matter hyperintensity with insular cortical atrophy on neuroimaging. Less constant or later findings were epilepsia partialis continua, oligoclonal bands, and serum anti-GluR3 antibodies. Conclusions: The association of partial seizures with focal EEG and neuroimaging changes allows a tentative diagnosis of RE 4 to 6 months after first symptoms.

Original languageEnglish
Pages (from-to)422-425
Number of pages4
JournalNeurology
Volume60
Issue number3
Publication statusPublished - Feb 11 2003

ASJC Scopus subject areas

  • Neuroscience(all)

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    Granata, T., Gobbi, G., Spreafico, R., Vigevano, F., Capovilla, G., Ragona, F., Freri, E., Chiapparini, L., Bernasconi, P., Giordano, L., Bertani, G., Casazza, M., Bernardina, B. D., & Fusco, L. (2003). Rasmussen's encephalitis: Early characteristics allow diagnosis. Neurology, 60(3), 422-425.